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dc.contributor.authorLillås, Bjørn Steinar
dc.contributor.authorQvale, Tor Hatlestad
dc.contributor.authorRichter, Blazej Konrad
dc.contributor.authorVikse, Bjørn Egil
dc.date.accessioned2021-11-29T07:48:54Z
dc.date.available2021-11-29T07:48:54Z
dc.date.created2021-11-22T23:26:21Z
dc.date.issued2021
dc.identifier.issn2468-0249
dc.identifier.urihttps://hdl.handle.net/11250/2831788
dc.description.abstractIntroduction Low birth weight (LBW) is associated with increased risk of kidney disease due to lower nephron endowment leading to hyperfiltration and subsequent nephron loss. Kidney size is commonly used as a proxy for nephron number. We compared kidney volume measured by magnetic resonance imaging (MRI) with measured glomerular filtration rate (mGFR) in adults with either normal birth weight (NBW) or low birth weight (LBW). Methods Healthy individuals aged 42 to 52 years with LBW (1100−2300 g) and NBW (3500 −4000 g) were invited to participate. The GFR was measured using plasma clearance of iohexol. Kidney volume was measured on magnetic resonance images using axial T2 images and coronal T1 images with fat saturation without contrast enhancement; calculations were performed according to the ellipsoid formula π/6 × length × width × depth. Results We included 102 individuals (54 LBW and 48 NBW). Total kidney volume was 302 ± 51 ml for female NBW vs 258 ± 48 ml for female LBW individuals (P = 0.002). For male individuals, total kidney volume was 347 ± 51 ml vs. 340 ± 65 ml (P = 0.7). The mGFR was significantly associated with kidney volume, with r = 0.52 (P < 0.001) for women and r = 0.39 (P = 0.007) for men. A mediation analysis showed that the association between birth weight and mGFR (significant in total sample and women) was mediated by kidney volume. Conclusion Healthy female individuals born with LBW have smaller kidneys than healthy females born with NBW. The previously shown associations between LBW and lower mGFR in adult women might be explained by smaller kidney volume.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleBirth Weight Is Associated With Kidney Size in Middle-Aged Womenen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 International Society of Nephrologyen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.ekir.2021.08.029
dc.identifier.cristin1957539
dc.source.journalKidney International Reportsen_US
dc.source.pagenumber2794-2802en_US
dc.identifier.citationKidney International Reports. 2021, 6 (11), 2794-2802.en_US
dc.source.volume6en_US
dc.source.issue11en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal