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dc.contributor.authorEngjom, Trond
dc.contributor.authorNordaas, Ingrid Kvåle
dc.contributor.authorTjora, Erling
dc.contributor.authorDimcevski, Georg Gjorgji
dc.contributor.authorHaldorsen, Ingfrid S.
dc.contributor.authorOlesen, Søren Schou
dc.contributor.authorDrewes, Asbjørn Mohr
dc.contributor.authorZviniene, Kristina
dc.contributor.authorBarauskas, Giedrus
dc.contributor.authorRiis Jespersen, Hans Søe
dc.contributor.authorJensen, Nanna
dc.contributor.authorBorch, Anders
dc.contributor.authorNøjgaard, Camilla
dc.contributor.authorNovovic, Srdan
dc.contributor.authorKardasheva, Svetlana S.
dc.contributor.authorOkhlobystin, Alexey
dc.contributor.authorHauge, Truls
dc.contributor.authorWaage, Anne
dc.contributor.authorFrøkjær, Jens Brøndum
dc.description.abstractObjectives The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies of limited sample size. We aimed to use a large dataset to explore associations between aetiology and pancreatic morphology in CP. Methods Subjects with definite or probable CP according to the M-ANNHEIM diagnostic criteria were included in this multicentre cross-sectional observational study and assessed using a standardized and validated CP imaging system. We performed multivariate logistic regression to analyse if aetiological factors adjusted for covariates were independently associated with morphological pancreatic features. Results We included 959 patients (66% males). Mean (SD) age was 55 (14) years. Pancreatic structural changes were found in 94% of the subjects: 67% had calcifications, 59% main pancreatic duct dilatation, 33% pseudo-cysts and 22% pancreatic atrophy. Alcohol abuse was independently associated with pancreatic calcifications (odds ratio (OR, [95% CI]); 1.61, [1.09, 2.37]) and focal acute pancreatitis (OR; 2.13, [1.27, 3.56]), whereas smoking was independently associated with more severe calcifications (OR; 2.09, [1.34, 3.27]) and involvement of the whole gland (OR; 2.29, [1.61, 3.28]). Disease duration was positively associated with calcifications (OR; (per year) 1.05 [1.02, 1.08]) and pancreatic atrophy (OR; 1.05 [1.02, 1.08]) and negatively associated with focal acute pancreatitis (OR 0.91, [0.87, 0.95] and pseudo cysts (OR; 0.96, [0.93, 0.98]). Conclusion In this large-scale study, etiological risk factors and disease duration in CP were independently associated with specific structural pancreatic imaging changes.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleAetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging databaseen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 Elsevieren_US
dc.source.journalPancreatology (Print)en_US
dc.identifier.citationPancreatology (Print). 2021, 21 (4), 688-697.en_US

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