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dc.contributor.authorBudal, Elisabeth Berge
dc.contributor.authorEbbing, Cathrine
dc.contributor.authorKessler, Jørg
dc.contributor.authorBains, Sukhjeet
dc.contributor.authorHaugen, Olav H.
dc.contributor.authorAukland, Stein Magnus
dc.contributor.authorEide, Geir Egil
dc.contributor.authorHalvorsen, Thomas
dc.contributor.authorBentsen, Mariann
dc.contributor.authorCollett, Karin
dc.description.abstractAim We evaluated the role of placental pathology in predicting adverse outcomes for neonates born extremely preterm (EPT) before 28 weeks of gestation. Methods This was a prospective observational study of 123 extremely preterm singletons born in a hospital in western Norway, and the placentas were classified according to the Amsterdam criteria. The associations between histologic chorioamnionitis (HCA), by the presence or the absence of a foetal inflammatory response (FIR+ or FIR−), maternal vascular malperfusion (MVM) as a whole and adverse neonatal outcomes were evaluated by logistic regression analyses. Adverse outcomes were defined as perinatal death, necrotising enterocolitis (NEC), bronchopulmonary dysplasia (BPD), brain pathology by magnetic resonance imaging at term-equivalent age, retinopathy of prematurity and early-onset neonatal sepsis. The results are reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results HCA was associated with NEC (OR 12.2, 95% CI 1.1 to 137.1). HCA/FIR+ was associated with BPD (OR 14.9, 95% CI 1.8–122.3) and brain pathology (OR 9.8, 95% CI 1.4–71.6), but HCA/FIR− was not. The only neonatal outcome that MVM was associated with was low birthweight. Conclusion Placental histology provided important information when assessing the risk of adverse neonatal outcomes following EPT birth.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titlePlacental histology predicted adverse outcomes in extremely premature neonates in Norway-population-based studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalActa Paediatricaen_US
dc.identifier.citationActa Paediatrica. 2021en_US

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