Show simple item record

dc.contributor.authorNerpin, Elisabet
dc.contributor.authorFerreira, Diogenes Seraphim
dc.contributor.authorWeyler, Joost
dc.contributor.authorSchlunnsen, Vivi
dc.contributor.authorJogi, Rain
dc.contributor.authorRaherison, Chantal
dc.contributor.authorGislasson, Thorainn
dc.contributor.authorDemoly, Pascal
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorNowak, Dennis
dc.contributor.authorCorsico, Angelo
dc.contributor.authorAccordini, Simone
dc.contributor.authorMarcon, Alessandro
dc.contributor.authorSquillacioti, Giulia
dc.contributor.authorOlivieri, Mario
dc.contributor.authorNielsen, Rune
dc.contributor.authorJohannessen, Ane
dc.contributor.authorReal, Francisco Gomez
dc.contributor.authorGarcia-Aymerich, Judith
dc.contributor.authorUrrutia, Isabel
dc.contributor.authorPereira-Vega, Antonio
dc.contributor.authorGullón, José-Antonio
dc.contributor.authorOlin, Anna-Carin
dc.contributor.authorForsberg, Bertil
dc.contributor.authorEmilsson, Össur Ingi
dc.contributor.authorPin, Isabelle
dc.contributor.authorJarvis, Deborah
dc.contributor.authorJanson, Christer
dc.contributor.authorMalinovschi, Andrei
dc.description.abstractBackground Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. Objectives To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. Methods Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. Results Among asthmatic subjects, higher percentage declines of FEV1 and FEV1/FVC were associated with higher FeNO levels (p = 0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p = 0.001) and females (p = 0.001) in stratified analyses. Percentage increase in FEV1 after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV1 and FeNO levels in non-smokers and women, regardless of asthma status. Conclusions We found a relationship between elevated FeNO and larger FEV1 decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking statusen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s).en_US
dc.source.journalWorld Allergy Organization Journalen_US
dc.identifier.citationWorld Allergy Organization Journal. 2021, 14 (5), 100544.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal