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dc.contributor.authorLiu, Xiaozheng
dc.contributor.authorRulina, Anastasiia
dc.contributor.authorChoi, Man Hung
dc.contributor.authorPedersen, Line
dc.contributor.authorLepland, Johanna
dc.contributor.authorTakle, Sina Thorsen
dc.contributor.authorMadeleine, Noëlly
dc.contributor.authorPeters, Stacey D'mello
dc.contributor.authorWogsland, Cara Ellen
dc.contributor.authorGrøndal, Sturla Magnus
dc.contributor.authorLorens, James Bradley
dc.contributor.authorGoodarzi, Hani
dc.contributor.authorLønning, Per Eystein
dc.contributor.authorKnappskog, Stian
dc.contributor.authorMolven, Anders
dc.contributor.authorHalberg, Nils Henrik
dc.date.accessioned2022-02-08T15:10:12Z
dc.date.available2022-02-08T15:10:12Z
dc.date.created2022-02-07T13:06:59Z
dc.date.issued2022
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11250/2977797
dc.description.abstractEpidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer cells. However, the cancer cell-autonomous mechanisms underlying this correlation are not well defined. Here we demonstrate that obesity-associated tumor formation is driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population. While there is no correlation with specific mutations, cellular adaptation to obesity is governed by palmitic acid (PA) and leads to enhanced tumor formation capacity of breast cancer cells. This process is governed epigenetically through increased chromatin occupancy of the transcription factor CCAAT/enhancer-binding protein beta (C/EBPB). Obesity-induced epigenetic activation of C/EBPB regulates cancer stem-like properties by modulating the expression of key downstream regulators including CLDN1 and LCN2. Collectively, our findings demonstrate that obesity drives cellular adaptation to PA drives tumor initiation in the obese setting through activation of a C/EBPB dependent transcriptional network.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleC/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast canceren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.articlenumber69en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41467-021-27734-2
dc.identifier.cristin1998569
dc.source.journalNature Communicationsen_US
dc.identifier.citationNature Communications. 2022, 13, 69.en_US
dc.source.volume13en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal