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dc.contributor.authorBolton, Charlotte M.
dc.contributor.authorBekaert, Michaël
dc.contributor.authorEilertsen, Mariann
dc.contributor.authorHelvik, Jon Vidar
dc.contributor.authorMigaud, Herve
dc.date.accessioned2022-04-07T08:58:10Z
dc.date.available2022-04-07T08:58:10Z
dc.date.created2021-12-02T11:18:40Z
dc.date.issued2021
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/11250/2990428
dc.description.abstractTo better understand the complexity of clock genes in salmonids, a taxon with an additional whole genome duplication, an analysis was performed to identify and classify gene family members (clock, arntl, period, cryptochrome, nr1d, ror, and csnk1). The majority of clock genes, in zebrafish and Northern pike, appeared to be duplicated. In comparison to the 29 clock genes described in zebrafish, 48 clock genes were discovered in salmonid species. There was also evidence of species-specific reciprocal gene losses conserved to the Oncorhynchus sister clade. From the six period genes identified three were highly significantly rhythmic, and circadian in their expression patterns (per1a.1, per1a.2, per1b) and two was significantly rhythmically expressed (per2a, per2b). The transcriptomic study of juvenile Atlantic salmon (parr) brain tissues confirmed gene identification and revealed that there were 2,864 rhythmically expressed genes (p < 0.001), including 1,215 genes with a circadian expression pattern, of which 11 were clock genes. The majority of circadian expressed genes peaked 2 h before and after daylight. These findings provide a foundation for further research into the function of clock genes circadian rhythmicity and the role of an enriched number of clock genes relating to seasonal driven life history in salmonids.en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleRhythmic Clock Gene Expression in Atlantic Salmon Parr Brainen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.articlenumber761109en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3389/fphys.2021.761109
dc.identifier.cristin1963269
dc.source.journalFrontiers in Physiologyen_US
dc.relation.projectNorges forskningsråd: 254894en_US
dc.identifier.citationFrontiers in Physiology. 2021, 12, 761109.en_US
dc.source.volume12en_US


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