dc.contributor.author | Aarsetøy, Reidun | |
dc.contributor.author | ten Cate, Hugo | |
dc.contributor.author | Spronk, Henri | |
dc.contributor.author | Van Oerle, Rene | |
dc.contributor.author | Aarsetøy, Hildegunn | |
dc.contributor.author | Staines, Harry | |
dc.contributor.author | Nilsen, Dennis W.T. | |
dc.date.accessioned | 2022-04-12T10:37:59Z | |
dc.date.available | 2022-04-12T10:37:59Z | |
dc.date.created | 2021-07-15T17:53:37Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0049-3848 | |
dc.identifier.uri | https://hdl.handle.net/11250/2991051 | |
dc.description.abstract | Background
Cardiac arrest and cardiopulmonary resuscitation (CPR) are associated with activated coagulation and microvascular fibrin deposition with subsequent multiorgan failure and adverse outcome.
Objectives
Activated Factor XI-antithrombin (FXIa-AT) complex, activated Factor IX–antithrombin (FIXa-AT) complex and thrombin-antithrombin (TAT) complex were measured as markers of coagulation activation, and evaluated as independent prognostic indicators in out-of-hospital cardiac arrest (OHCA) patients.
Methods
From February 2007 until December 2010 blood samples were collected in close approximation to CPR from patients with OHCA of assumed cardiac origin. Follow-up samples in survivors were drawn 8–12 h and 24–48 h after hospital admission. All measurements were determined by ELISA.
Results
Thirty-seven patients presented with asystole and 77 with ventricular fibrillation as first recorded heart rhythm. At 30-days follow-up, 70 patients (61.4%) had died. All patients had elevated levels of FXIa-AT complex, FIXa-AT complex and TAT. Initial levels were significantly higher in non-survivors compared to 30-days survivors.
A significant increase in risk of 30-days all-cause mortality was observed through increasing quartiles of all three biomarkers in univariate Cox regression analysis. Compared to the lowest quartile (Q1), only FXIa-AT complex levels in Q3 (HR 3.17, p = 0.011) and Q2 (HR 3.02, p = 0.016) were independently associated with all-cause mortality in the multivariable analysis. FIXa-AT complex and TAT-complex did not behave as independent predictors.
Conclusions
Complexes of FXIa-AT were independently associated with 30-days survival in OHCA-patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1016/j.thromres.2021.05.014 | |
dc.identifier.cristin | 1921900 | |
dc.source.journal | Thrombosis Research | en_US |
dc.source.pagenumber | 1-8 | en_US |
dc.identifier.citation | Thrombosis Research. 2021, 204, 1-8. | en_US |
dc.source.volume | 204 | en_US |