Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
dc.contributor.author | Aarsetøy, Reidun | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Michelsen, Annika E. | |
dc.contributor.author | de la Fuente, Ricardo Leon | |
dc.contributor.author | Pønitz, Volker | |
dc.contributor.author | Andersen, Trygve Brugger | |
dc.contributor.author | Grundt, Heidi | |
dc.contributor.author | Staines, Harry | |
dc.contributor.author | Nilsen, Dennis W.T. | |
dc.date.accessioned | 2022-04-12T10:52:21Z | |
dc.date.available | 2022-04-12T10:52:21Z | |
dc.date.created | 2021-07-23T20:03:58Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0954-6820 | |
dc.identifier.uri | https://hdl.handle.net/11250/2991060 | |
dc.description.abstract | Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a hospitalized Norwegian patient cohort (n = 871) with suspected acute coronary syndrome (ACS) and validated our results in a similar Argentinean cohort (n = 982). Methods A cox regression model, adjusting for traditional cardiovascular risk factors, was fitted for ANGPT2 and ANGPTL4, respectively, with all-cause mortality and cardiac death within 24 months and all-cause mortality within 60 months as the dependent variables. Results At 24 months follow-up, 138 (15.8%) of the Norwegian and 119 (12.1%) of the Argentinian cohort had died, of which 86 and 66 deaths, respectively, were classified as cardiac. At 60 months, a total of 259 (29.7%) and 173 (17.6%) patients, respectively, had died. ANGPT2 was independently associated with all-cause mortality in both cohorts at 24 months [hazard ratio (HR) 1.27 (95% confidence interval (CI), 1.08–1.50) for Norway, and HR 1.57 (95% CI, 1.27–1.95) for Argentina], with similar results at 60 months [HR 1.19 (95% CI, 1.05–1.35) (Norway), and HR 1.56 (95% CI, 1.30–1.88) (Argentina)], and was also significantly associated with cardiac death [HR 1.51 (95% CI, 1.14–2.00)], in the Argentinean population. ANGPTL4 was significantly associated with all-cause mortality in the Argentinean cohort at 24 months [HR 1.39 (95% CI, 1.15–1.68)] and at 60 months [HR 1.43 (95% CI, 1.23–1.67)], enforcing trends in the Norwegian population. Conclusions ANGPT2 and ANGPTL4 were significantly associated with outcome in similar ACS patient cohorts recruited on two continents. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1111/joim.13339 | |
dc.identifier.cristin | 1922528 | |
dc.source.journal | Journal of Internal Medicine | en_US |
dc.source.pagenumber | 894-909 | en_US |
dc.identifier.citation | Journal of Internal Medicine. 2021, 290 (4), 894-909. | en_US |
dc.source.volume | 290 | en_US |
dc.source.issue | 4 | en_US |
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