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dc.contributor.authorTillmann, Sandra
dc.contributor.authorAwwad, Hussain M.
dc.contributor.authorMacPherson, Chad W.
dc.contributor.authorHapp, Denise F.
dc.contributor.authorTreccani, Giulia
dc.contributor.authorGeisel, Juergen
dc.contributor.authorTompkins, Thomas A.
dc.contributor.authorUeland, Per Magne
dc.contributor.authorWegener, Gregers
dc.contributor.authorObeid, Rima
dc.description.abstractScope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This study used Sprague Dawley rats to investigate whether a methyl-deficient diet (MDD) may influence tryptophan/kynurenine pathways and cytokines and whether probiotics can mitigate these effects. Methods and Results Rats are fed a control or MDD diet. Animals on the MDD diet received vehicle, probiotics (L. helveticus R0052 and B. longum R0175), choline, or probiotics + choline for 10 weeks (n = 10 per group). Concentrations of plasma kynurenine metabolites and the methylation and inflammatory markers in plasma and liver are measured. Results MDD animals (vs controls) show upregulation of plasma kynurenine, kynurenic acid, xanthurenic acid, 3-hydroxyxanthranilic acid, quinolinic acid, nicotinic acid, and nicotinamide (all p < 0.05). In the MDD rats, the probiotics (vs vehicle) cause lower anthranilic acid and a trend towards lower kynurenic acid and picolinic acid. Compared to probiotics alone, probiotics + choline is associated with a reduced enrichment of the bacterial strains in cecum. The interventions have no effect on inflammatory markers. Conclusions Probiotics counterbalance the effect of MDD diet and downregulate downstream metabolites of the kynurenine pathway.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probioticsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalMolecular Nutrition & Food Researchen_US
dc.identifier.citationMolecular Nutrition & Food Research. 2021, 65 (9), 2100078.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal