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dc.contributor.authorÖzgümüs, Türküler
dc.contributor.authorSulaieva, Oksana
dc.contributor.authorJain, Ruchi
dc.contributor.authorArtner, Isabella
dc.contributor.authorLyssenko, Valeriya
dc.date.accessioned2022-04-19T13:06:16Z
dc.date.available2022-04-19T13:06:16Z
dc.date.created2022-02-04T14:43:30Z
dc.date.issued2021
dc.identifier.issn2296-634X
dc.identifier.urihttps://hdl.handle.net/11250/2991354
dc.description.abstractPerinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light on molecular consequences of exposure to short-time glucose starvation on the transcriptome profile of mouse embryonic retinal cells. We found a profound downregulation of genes regulating development of retinal neurons, which was accompanied by reduced expression of genes encoding for glycolytic enzymes and glutamatergic signaling. At the same time, glial and vascular markers were upregulated, mimicking the diabetes-associated increase of angiogenesis—a hallmark of pathogenic features in diabetic retinopathy. Energy deprivation as a consequence of starvation to glucose seems to be compensated by upregulation of genes involved in fatty acid elongation. Results from the present study demonstrate that short-term glucose deprivation during early fetal life differentially alters expression of metabolism- and function-related genes and could have detrimental and lasting effects on gene expression in the retinal neurons, glial cells, and vascular elements and thus potentially disrupting gene regulatory networks essential for the formation of the retinal neurovascular unit. Abnormal developmental programming during retinogenesis may serve as a trigger of reactive gliosis, accelerated neurodegeneration, and increased vascularization, which may promote development of severe retinopathy in patients with diabetes later in life.en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleStarvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cellsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.articlenumber726852en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3389/fcell.2021.726852
dc.identifier.cristin1997932
dc.source.journalFrontiers in Cell and Developmental Biologyen_US
dc.identifier.citationFrontiers in Cell and Developmental Biology. 2021, 9, 726852.en_US
dc.source.volume9en_US


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