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dc.contributor.authorMullins, Niamh
dc.contributor.authorKang, JooEun
dc.contributor.authorCampos, Adrian I.
dc.contributor.authorColeman, Jonathan R.I.
dc.contributor.authorEdwards, Alexis C.
dc.contributor.authorGalfalvy, Hanga
dc.contributor.authorLevey, Daniel F.
dc.contributor.authorLori, Adriana
dc.contributor.authorShabalin, Andrey A
dc.contributor.authorAndreassen, Ole
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMorken, Gunnar
dc.contributor.authorStarnawska, Anna
dc.contributor.authorSu, Mei-Hsin
dc.contributor.authorWatson, Hunna J
dc.contributor.authorAdams, Mark
dc.contributor.authorAwasthi, Swapnil
dc.contributor.authorGandal, Michael
dc.contributor.authorHafferty, Jonathan
dc.contributor.authorHishimoto, Akitoyo
dc.contributor.authorKim, Minsoo
dc.contributor.authorOkazaki, Satoshi
dc.contributor.authorOtsuka, Ikuo
dc.contributor.authorWare, Erin B.
dc.contributor.authorStephan, Ripke
dc.contributor.authorBergen, Andrew W.
dc.contributor.authorBerrettini, Wade H.
dc.contributor.authorBohus, Martin
dc.contributor.authorBrandt, Harry
dc.contributor.authorChang, Xiao
dc.contributor.authorChen, Wei J
dc.contributor.authorChen, Hsi-Chung
dc.contributor.authorCrawford, Steven
dc.contributor.authorCrow, Scott
dc.contributor.authorDiBlasi, Emily
dc.contributor.authorDuriez, Philibert
dc.contributor.authorFichter, Manfred M
dc.contributor.authorFernández-Aranda, Fernando
dc.contributor.authorGallinger, Steven
dc.contributor.authorGlatt, Stephen J.
dc.contributor.authorGorwood, Philip
dc.contributor.authorGuo, Yiran
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorHalmi, Katherine A
dc.contributor.authorHwu, Hai-Gwo
dc.contributor.authorJain, Sonia
dc.contributor.authorJamain, Stephane
dc.contributor.authorJimenez-Murcia, Susana
dc.contributor.authorJohnson, Craig
dc.contributor.authorDjurovic, Srdjan
dc.description.abstractBackground Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleDissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factorsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 Society of Biological Psychiatryen_US
dc.source.journalBiological Psychiatryen_US
dc.identifier.citationBiological Psychiatry. 2022, 91 (3), 313-327.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal