Vis enkel innførsel

dc.contributor.authorStrømme, Maria Fagerbakke
dc.contributor.authorMellesdal, Liv Solrunn
dc.contributor.authorBartz-Johannessen, Christoffer
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorKrogenes, Marianne Leiknes
dc.contributor.authorMehlum, Lars
dc.contributor.authorJohnsen, Erik
dc.date.accessioned2022-05-30T12:42:06Z
dc.date.available2022-05-30T12:42:06Z
dc.date.created2022-05-09T14:15:33Z
dc.date.issued2022
dc.identifier.issn0271-0749
dc.identifier.urihttps://hdl.handle.net/11250/2996869
dc.description.abstractPurpose: Little is known about the impact of different psychotropic drugs on acute readmission risk, when used concomitantly in a real-life setting. We aimed to investigate the association between acute readmission risk and use of antipsychotic drugs, antidepressants, mood stabilizers, and benzodiazepines in patients with schizophrenia. Methods: A cohort study included all patients diagnosed with schizophrenia admitted to a psychiatric acute unit at Haukeland University Hospital in Bergen, Norway, during a 10-year period (N = 663). Patients were followed from discharge until first readmission or censoring. Cox multiple regression analyses were conducted using antipsychotic drugs, antidepressants, mood stabilizers, and benzodiazepines as time-dependent variables, and periods of use and nonuse were compared within individual patients. Adjustments were made for sex, age at index admission, and excessive use of alcohol and illicit substances. Results: A total of 410 patients (61.8%) were readmitted during follow-up, and the mean and median times in days to readmission were 709 and 575, respectively. Compared with nonuse, the use of antipsychotic drugs was associated with reduced risk of readmission (adjusted hazards ratio, 0.20; P < 0.01; confidence interval, 0.16–0.24), and the use of benzodiazepines was associated with increased risk of readmission (adjusted hazards ratio, 1.51; P < 0.01; confidence interval, 1.13–2.02). However, no relation to readmission risk was found for the use of antidepressants and mood stabilizers. Conclusions: We found that use of benzodiazepines and antipsychotic drugs are inversely associated with acute readmission risk in schizophrenia.en_US
dc.language.isoengen_US
dc.publisherWolters Kluweren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleUse of Benzodiazepines and Antipsychotic Drugs Are Inversely Associated with Acute Readmission Risk in Schizophreniaen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 the authorsen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1097/JCP.0000000000001497
dc.identifier.cristin2022759
dc.source.journalJournal of Clinical Psychopharmacologyen_US
dc.source.pagenumber37-42en_US
dc.identifier.citationJournal of Clinical Psychopharmacology. 2022, 42 (1), 37-42.en_US
dc.source.volume42en_US
dc.source.issue1en_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal