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dc.contributor.authorLjungblad, Ulf Wike
dc.contributor.authorAstrup, Henriette
dc.contributor.authorMørkrid, Lars
dc.contributor.authorHager, Helle Borgstrøm
dc.contributor.authorLindberg, Morten
dc.contributor.authorEklund, Erik A.
dc.contributor.authorMonsen, Anne-Lise Bjørke
dc.contributor.authorRootwelt-Revheim, Terje
dc.contributor.authorTangeraas, Trine
dc.description.abstractBackground: In Norway, 5-10% of neonates and infants have biomarkers suggesting vitamin B12 deficiency from newborn screening tests and unselected clinical screening, respectively. Aims: The aims were to identify risk factors and describe presenting symptoms and biochemical profiles in infants diagnosed with vitamin B12 deficiency. Methods: In this case-control study, we searched hospital medical records for infants younger than one year born in 2011-2018, diagnosed with vitamin B12 deficiency. We compared 85 cases with a control group of 252 infants aged 3-7 months. Parents completed questionnaires. Results: Of the 85 cases with vitamin B12 deficiency, 80% presented with spells (37%) of apneas, motor seizures, or absences within the first two months of life. Tremor (29%) and irritability (18%) were the most common findings at the first examination. Serum total homocysteine ≥10 μmol/L was found in 77% of cases compared to 28% of controls (P < 0.001). None of the mothers were vegetarians, but 25% reported a previous history of vitamin B12 deficiency and 7% had celiac disease. The dose of nitrous oxide given during labor was significantly associated with infant serum total homocysteine level at diagnosis (r = 0.37, 95% confidence interval = 0.16-0.55, P < 0.001) for cases, but not for controls. Conclusion: Spells, tremor, and irritability are common findings in early infant vitamin B12 deficiency. Nitrous oxide given during labor is proposed as a contributing risk factor to the development of early infant vitamin B12 deficiency.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBreastfed Infants With Spells, Tremor, or Irritability: Rule Out Vitamin B12 Deficiencyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.journalPediatric Neurologyen_US
dc.identifier.citationPediatric Neurology. 2022, 131, 4-12.en_US

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Navngivelse 4.0 Internasjonal
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