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dc.contributor.authorBjarke, Jill Kristin
dc.contributor.authorGjerde, Helga Nødland
dc.contributor.authorJørgensen, Hugo A
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorLøberg, Else-Marie
dc.contributor.authorJohnsen, Erik
dc.date.accessioned2022-08-05T13:47:50Z
dc.date.available2022-08-05T13:47:50Z
dc.date.created2022-04-10T16:35:52Z
dc.date.issued2022
dc.identifier.issn0924-2708
dc.identifier.urihttps://hdl.handle.net/11250/3010407
dc.description.abstractObjective: Akathisia is among the most unpleasant side effects related to antipsychotic drug (AP) use, and possible associations between akathisia and agitation, depression and suicidal behaviour, respectively, have been described in previous literature. New generation antipsychotics are however regarded less prone to induce this particular adverse effect compared to older drugs, but evidence is incomplete and in need of confirmation from clinically relevant samples and settings. We, therefore, aim to investigate akathisia at hospital discharge for patients consecutively admitted with acute-phase psychosis and treated with atypical antipsychotics according to guideline-concordant clinical practice. Methods: This exploratory study is part of a naturalistic randomised controlled study in patients admitted with acute phase psychosis (N = 109). We report cross-sectional data at discharge/first follow-up after acute psychiatric hospital admission for patients with schizophrenia and related psychotic disorders. Results: There were statistically significant positive associations between akathisia and the following; suicidality in men (Beta 0.306, p = 0.048), but not in women; agitation in those previously unexposed to antipsychotics (Beta 0.288, p = 0.047) and depression in those exposed to antipsychotics before hospital admittance (Beta 0.375, p = 0.031). Conclusion: Main findings were that akathisia is still a prevalent side effect in a clinically relevant sample of patients treated with atypical antipsychotics. Our results suggest that akathisia is significantly associated with depression, suicidality and agitation in different subgroups of patients receiving APs. Akathisia can be detrimental and the relations between akathisia and depression, suicidality and agitation should be investigated further in prospective, hypothesis-testing studies with larger samples.en_US
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.relation.urihttps://doi.org/10.1017/neu.2022.9
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAkathisia and atypical antipsychotics. Relation to suicidality, agitation and depression in a clinical trialen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1017/neu.2022.9
dc.identifier.cristin2016530
dc.source.journalActa Neuropsychiatricaen_US
dc.identifier.citationActa Neuropsychiatrica. 2022en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal