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dc.contributor.authorVigeland, Maria Dehli
dc.contributor.authorFlåm, Siri Tennebø
dc.contributor.authorVigeland, Magnus Dehli
dc.contributor.authorEspeland, Ansgar
dc.contributor.authorKristoffersen, Per Martin
dc.contributor.authorVetti, Nils
dc.contributor.authorWigemyr, Monica
dc.contributor.authorBråten, Lars Christian Haugli
dc.contributor.authorGjefsen, Elisabeth
dc.contributor.authorSchistad, Ellina Iordanova
dc.contributor.authorHaugen, Anne Julsrud
dc.contributor.authorJohanessen, Anne Froholdt
dc.contributor.authorSkouen, Jan Sture
dc.contributor.authorZwart, John Anker Henrik
dc.contributor.authorStorheim, Kjersti
dc.contributor.authorPedersen, Linda Margareth
dc.contributor.authorLie, Benedicte Alexandra
dc.date.accessioned2022-08-15T08:11:05Z
dc.date.available2022-08-15T08:11:05Z
dc.date.created2022-05-12T09:35:45Z
dc.date.issued2022-01-07
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/3011771
dc.description.abstractDisability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow lesions. The cause of such changes and their relationship to pain are not yet understood. We explored the pathobiology of these lesions using profiling of gene expression in blood, coupled with an edema-sensitive MRI technique known as short tau inversion recovery (STIR) imaging. STIR images and total RNA from blood were collected from 96 patients with chronic LBP and MC type I, the most inflammatory MC state. We found the expression of 37 genes significantly associated with STIR signal volume, ten genes with edema abundancy (a constructed combination of STIR signal volume, height, and intensity), and one gene with expression levels significantly associated with maximum STIR signal intensity. Gene sets related to interferon signaling, mitochondrial metabolism and defense response to virus were identified as significantly enriched among the upregulated genes in all three analyses. Our results point to inflammation and immunological defense as important players in MC biology in patients with chronic LBP.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCorrelation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvementen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.articlenumber215en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41598-021-04189-5
dc.identifier.cristin2023772
dc.source.journalScientific Reportsen_US
dc.identifier.citationScientific Reports. 2022, 12 (1), 215.en_US
dc.source.volume12en_US
dc.source.issue1en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal