Trends in Mortality Due to Myocardial Infarction, Stroke, and Pulmonary Embolism in Patients Receiving Dialysis
dc.contributor.author | Ocak, Gurbey | |
dc.contributor.author | Boenink, Rianne | |
dc.contributor.author | Noordzij, Marlies | |
dc.contributor.author | Bos, Willem Jan W. | |
dc.contributor.author | Vikse, Bjørn Egil | |
dc.contributor.author | Cases, Aleix | |
dc.contributor.author | Kerschbaum, Julia | |
dc.contributor.author | Helve, Jaakko | |
dc.contributor.author | Nordio, Maurizio | |
dc.contributor.author | Arici, Mustafa | |
dc.contributor.author | Mercadal, Lucile | |
dc.contributor.author | Wanner, Christoph | |
dc.contributor.author | Palsson, Runolfur | |
dc.contributor.author | Hommel, Kristine | |
dc.contributor.author | De Meester, Johan | |
dc.contributor.author | Kostopoulou, Myrto | |
dc.contributor.author | Santamaria, Rafael | |
dc.contributor.author | Rodrigo, Emilio | |
dc.contributor.author | Rydell, Helena | |
dc.contributor.author | Bell, Samira | |
dc.contributor.author | Massy, Ziad A. | |
dc.contributor.author | Jager, Kitty J. | |
dc.contributor.author | Kramer, Anneke | |
dc.date.accessioned | 2022-08-15T08:20:47Z | |
dc.date.available | 2022-08-15T08:20:47Z | |
dc.date.created | 2022-05-12T13:55:24Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2574-3805 | |
dc.identifier.uri | https://hdl.handle.net/11250/3011780 | |
dc.description.abstract | Importance: During the past decades, improvements in the prevention and management of myocardial infarction, stroke, and pulmonary embolism have led to a decline in cardiovascular mortality in the general population. However, it is unknown whether patients receiving dialysis have also benefited from these improvements. Objective: To assess the mortality rates for myocardial infarction, stroke, and pulmonary embolism in a large cohort of European patients receiving dialysis compared with the general population. Design, Setting, and Participants: In this cohort study, adult patients who started dialysis between 1998 and 2015 from 11 European countries providing data to the European Renal Association Registry were and followed up for 3 years. Data were analyzed from September 2020 to February 2022. Exposures: Start of dialysis. Main Outcomes and Measures: The age- and sex-standardized mortality rate ratios (SMRs) with 95% CIs were calculated by dividing the mortality rates in patients receiving dialysis by the mortality rates in the general population for 3 equal periods (1998-2003, 2004-2009, and 2010-2015). Results: In total, 220 467 patients receiving dialysis were included in the study. Their median (IQR) age was 68.2 (56.5-76.4) years, and 82 068 patients (37.2%) were female. During follow-up, 83 912 patients died, of whom 7662 (9.1%) died because of myocardial infarction, 5030 (6.0%) died because of stroke, and 435 (0.5%) died because of pulmonary embolism. Between the periods 1998 to 2003 and 2010 to 2015, the SMR of myocardial infarction decreased from 8.1 (95% CI, 7.8-8.3) to 6.8 (95% CI, 6.5-7.1), the SMR of stroke decreased from 7.3 (95% CI, 7.0-7.6) to 5.8 (95% CI, 5.5-6.2), and the SMR of pulmonary embolism decreased from 8.7 (95% CI, 7.6-10.1) to 5.5 (95% CI, 4.5-6.6). Conclusions and Relevance: In this cohort study of patients receiving dialysis, mortality rates for myocardial infarction, stroke, and pulmonary embolism decreased more over time than in the general population. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Medical Association | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Trends in Mortality Due to Myocardial Infarction, Stroke, and Pulmonary Embolism in Patients Receiving Dialysis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 the authors | en_US |
dc.source.articlenumber | e227624 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1001/jamanetworkopen.2022.7624 | |
dc.identifier.cristin | 2023957 | |
dc.source.journal | JAMA Network Open | en_US |
dc.identifier.citation | JAMA Network Open. 2022, 5 (4), e227624. | en_US |
dc.source.volume | 5 | en_US |
dc.source.issue | 4 | en_US |
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