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dc.contributor.authorOrmerod, Monica Bettina E. Greenwood
dc.contributor.authorUeland, Thor
dc.contributor.authorWerner, Maren Caroline Frogner
dc.contributor.authorHjell, Gabriela
dc.contributor.authorRødevand, Linn Nilsen
dc.contributor.authorSæther, Linn Sofie
dc.contributor.authorLunding, Synve Hoffart
dc.contributor.authorJohansen, Ingrid Torp
dc.contributor.authorUeland, Torill
dc.contributor.authorLagerberg, Trine Vik
dc.contributor.authorMelle, Ingrid
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorAndreassen, Ole
dc.contributor.authorSteen, Nils Eiel
dc.date.accessioned2022-09-12T11:29:04Z
dc.date.available2022-09-12T11:29:04Z
dc.date.created2022-08-15T19:23:27Z
dc.date.issued2022
dc.identifier.issn2666-3546
dc.identifier.urihttps://hdl.handle.net/11250/3017238
dc.description.abstractBackground Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have investigated how patterns across immune markers are related to diagnosis and illness course. Methods A total of 948 participants with a diagnosis of schizophrenia (SCZ, N = 602) or bipolar (BD, N = 346) spectrum disorder, and 814 healthy controls (HC) were included. Twenty-five immune markers comprising cell adhesion molecules (CAMs), interleukin (IL)-18-system factors, defensins, chemokines and other markers, related to neuroinflammation, blood-brain barrier (BBB) function, inflammasome activation and immune cell orchestration were analyzed. Eight immune principal component (PC) scores were constructed by PC Analysis (PCA) and applied in general linear models with diagnosis and illness course characteristics. Results Three PC scores were significantly associated with a SCZ and/or BD diagnosis (HC reference), with largest, however small, effect sizes of scores based on CAMs, BBB markers and defensins (p < 0.001, partial η2 = 0.02–0.03). Number of psychotic episodes per year in SCZ was associated with a PC score based on IL-18 system markers and the potential neuroprotective cytokine A proliferation-inducing ligand (p = 0.006, partial η2 = 0.071). Conclusion Analyses of composite immune markers scores identified specific patterns suggesting CAMs-mediated BBB dysregulation pathways associated with SMDs and interrelated pro-inflammatory and neuronal integrity processes associated with severity of illness course. This suggests a complex pattern of immune pathways involved in SMDs and SCZ illness course.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleComposite immune marker scores associated with severe mental disorders and illness courseen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber100483en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.bbih.2022.100483
dc.identifier.cristin2043208
dc.source.journalBrain, Behavior, and Immunity - Health (BBI - Health)en_US
dc.identifier.citationBrain, Behavior, and Immunity - Health. 2022, 24, 100483.en_US
dc.source.volume24en_US


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