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dc.contributor.authorVogt, Elinor Margrethe Chelsom
dc.contributor.authorReal, Francisco Gomez
dc.contributor.authorHusebye, Eystein Sverre
dc.contributor.authorBjörnsdottir, Sigridur
dc.contributor.authorBenediktsdottir, Bryndis
dc.contributor.authorBertelsen, Randi Jacobsen
dc.contributor.authorDemoly, Pascal
dc.contributor.authorFranklin, Karl Anders
dc.contributor.authorGallastegui, Leire Sainz de Aja
dc.contributor.authorGonzález, Francisco Javier Callejas
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorHolm, Mathias
dc.contributor.authorJögi, Nils Oskar
dc.contributor.authorLeynaert, Benedicte
dc.contributor.authorLindberg, Eva
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorMartínez-Moratalla, Jesús
dc.contributor.authorMayoral, Raúl Godoy
dc.contributor.authorOudin, Anna
dc.contributor.authorPereira-Vega, Antonio
dc.contributor.authorSemjen, Chantal Raherison
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorTriebner, Kai Philipp
dc.contributor.authorØksnes, Marianne
dc.date.accessioned2022-09-16T12:28:32Z
dc.date.available2022-09-16T12:28:32Z
dc.date.created2022-09-13T18:54:48Z
dc.date.issued2022
dc.identifier.issn2049-3614
dc.identifier.urihttps://hdl.handle.net/11250/3018484
dc.description.abstractObjective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women. Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI. Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63–3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin. Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.en_US
dc.language.isoengen_US
dc.publisherBioScientificaen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titlePremature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohortsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Authorsen_US
dc.source.articlenumbere220024en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1530/EC-22-0024
dc.identifier.cristin2051407
dc.source.journalEndocrine Connectionsen_US
dc.identifier.citationEndocrine Connections. 2022, 11 (5), e220024.en_US
dc.source.volume11en_US
dc.source.issue5en_US


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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