dc.contributor.author | Vogt, Elinor Margrethe Chelsom | |
dc.contributor.author | Real, Francisco Gomez | |
dc.contributor.author | Husebye, Eystein Sverre | |
dc.contributor.author | Björnsdottir, Sigridur | |
dc.contributor.author | Benediktsdottir, Bryndis | |
dc.contributor.author | Bertelsen, Randi Jacobsen | |
dc.contributor.author | Demoly, Pascal | |
dc.contributor.author | Franklin, Karl Anders | |
dc.contributor.author | Gallastegui, Leire Sainz de Aja | |
dc.contributor.author | González, Francisco Javier Callejas | |
dc.contributor.author | Heinrich, Joachim | |
dc.contributor.author | Holm, Mathias | |
dc.contributor.author | Jögi, Nils Oskar | |
dc.contributor.author | Leynaert, Benedicte | |
dc.contributor.author | Lindberg, Eva | |
dc.contributor.author | Malinovschi, Andrei | |
dc.contributor.author | Martínez-Moratalla, Jesús | |
dc.contributor.author | Mayoral, Raúl Godoy | |
dc.contributor.author | Oudin, Anna | |
dc.contributor.author | Pereira-Vega, Antonio | |
dc.contributor.author | Semjen, Chantal Raherison | |
dc.contributor.author | Schlünssen, Vivi | |
dc.contributor.author | Triebner, Kai Philipp | |
dc.contributor.author | Øksnes, Marianne | |
dc.date.accessioned | 2022-09-16T12:28:32Z | |
dc.date.available | 2022-09-16T12:28:32Z | |
dc.date.created | 2022-09-13T18:54:48Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2049-3614 | |
dc.identifier.uri | https://hdl.handle.net/11250/3018484 | |
dc.description.abstract | Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.
Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.
Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.
Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63–3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.
Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BioScientifica | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Authors | en_US |
dc.source.articlenumber | e220024 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1530/EC-22-0024 | |
dc.identifier.cristin | 2051407 | |
dc.source.journal | Endocrine Connections | en_US |
dc.identifier.citation | Endocrine Connections. 2022, 11 (5), e220024. | en_US |
dc.source.volume | 11 | en_US |
dc.source.issue | 5 | en_US |