Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19
dc.contributor.author | Bruno, Raphael Romano | |
dc.contributor.author | Wernly, Bernhard | |
dc.contributor.author | Wolff, Georg | |
dc.contributor.author | Fjølner, Jesper | |
dc.contributor.author | Artigas, Antonio | |
dc.contributor.author | Bollen Pinto, Bernardo | |
dc.contributor.author | Schefold, Joerg C. | |
dc.contributor.author | Kindgen-Milles, Detlef | |
dc.contributor.author | Baldia, Philipp Heinrich | |
dc.contributor.author | Kelm, Malte | |
dc.contributor.author | Beil, Michael | |
dc.contributor.author | Sviri, Sigal | |
dc.contributor.author | van Heerden, Peter Vernon | |
dc.contributor.author | Szczeklik, Wojciech | |
dc.contributor.author | Topeli, Arzu | |
dc.contributor.author | Elhadi, Muhammed | |
dc.contributor.author | Joannidis, Michael | |
dc.contributor.author | Oeyen, Sandra | |
dc.contributor.author | Kondili, Eumorfia | |
dc.contributor.author | Marsh, Brian | |
dc.contributor.author | Andersen, Finn Husøy | |
dc.contributor.author | Moreno, Rui | |
dc.contributor.author | Leaver, Susannah | |
dc.contributor.author | Boumendil, Ariane | |
dc.contributor.author | De Lange, Dylan W. | |
dc.contributor.author | Guidet, Bertrand | |
dc.contributor.author | Flaatten, Hans Kristian | |
dc.contributor.author | Jung, Christian | |
dc.date.accessioned | 2022-10-28T11:44:02Z | |
dc.date.available | 2022-10-28T11:44:02Z | |
dc.date.created | 2022-10-19T13:27:31Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2055-5822 | |
dc.identifier.uri | https://hdl.handle.net/11250/3028856 | |
dc.description.abstract | Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. Methods and results Patients with pre-existing CHF were subclassified as having ischaemic or non-ischaemic cardiac disease; patients with a documented ejection fraction (EF) were subclassified according to heart failure EF: reduced (HFrEF, n = 132), mild (HFmrEF, n = 91), or preserved (HFpEF, n = 103). Associations of heart failure characteristics with the 30 day mortality were analysed in univariate and multivariate logistic regression analyses. Pre-existing CHF was reported in 566 of 3917 patients (14%). Patients with CHF were older, frailer, and had significantly higher SOFA scores on admission. CHF patients showed significantly higher crude 30 day mortality [60% vs. 48%, P < 0.001; odds ratio 1.87, 95% confidence interval (CI) 1.5–2.3] and 3 month mortality (69% vs. 56%, P < 0.001). After multivariate adjustment for confounders (SOFA, age, sex, and frailty), no independent association of CHF with mortality remained [adjusted odds ratio (aOR) 1.2, 95% CI 0.5–1.5; P = 0.137]. More patients suffered from pre-existing ischaemic than from non-ischaemic disease [233 vs. 328 patients (n = 5 unknown aetiology)]. There were no differences in baseline characteristics between ischaemic and non-ischaemic disease or between HFrEF, HFmrEF, and HFpEF. Crude 30 day mortality was significantly higher in HFrEF compared with HFpEF (64% vs. 48%, P = 0.042). EF as a continuous variable was not independently associated with 30 day mortality (aOR 0.98, 95% CI 0.9–1.0; P = 0.128). Conclusions In critically ill older COVID-19 patients, pre-existing CHF was not independently associated with 30 day mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1002/ehf2.13854 | |
dc.identifier.cristin | 2062811 | |
dc.source.journal | ESC Heart Failure | en_US |
dc.source.pagenumber | 1756-1765 | en_US |
dc.identifier.citation | ESC Heart Failure. 2022, 9 (3), 1756-1765. | en_US |
dc.source.volume | 9 | en_US |
dc.source.issue | 3 | en_US |
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