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dc.contributor.authorWeeland, Cees J.
dc.contributor.authorKasprzak, Selina
dc.contributor.authorde Joode, Niels T.
dc.contributor.authorAbe, Yoshinari
dc.contributor.authorAlonso, Pino
dc.contributor.authorAmeis, Stephanie H.
dc.contributor.authorAnticevic, Alan
dc.contributor.authorArnold, Paul D.
dc.contributor.authorBalachander, Srinivas
dc.contributor.authorBanaj, Nerisa
dc.contributor.authorBargallo, Nuria
dc.contributor.authorBatistuzzo, Marcelo C.
dc.contributor.authorBenedetti, Francesco
dc.contributor.authorBeucke, Jan C.
dc.contributor.authorBollettini, Irene
dc.contributor.authorBrecke, Vilde
dc.contributor.authorBrem, Silvia
dc.contributor.authorCappi, Carolina
dc.contributor.authorCheng, Yuqi
dc.contributor.authorCho, Kang Ik K.
dc.contributor.authorCosta, Daniel L. C.
dc.contributor.authorDallaspezia, Sara
dc.contributor.authorDenys, Damiaan
dc.contributor.authorEng, Goi Khia
dc.contributor.authorFerreira, Sónia
dc.contributor.authorFeusner, Jamie D.
dc.contributor.authorFontaine, Martine
dc.contributor.authorFouche, Jean-Paul
dc.contributor.authorGrazioplene, Rachael G.
dc.contributor.authorGruner, Patricia
dc.contributor.authorHe, Mengxin
dc.contributor.authorHirano, Yoshiyuki
dc.contributor.authorHoexter, Marcelo Q.
dc.contributor.authorHuyser, Chaim
dc.contributor.authorHu, Hao
dc.contributor.authorJaspers-Fayer, Fern
dc.contributor.authorKathmann, Norbert
dc.contributor.authorKaufmann, Christian
dc.contributor.authorKim, Minah
dc.contributor.authorKoch, Kathrin
dc.contributor.authorBin Kwak, Yoo
dc.contributor.authorKwon, Jun Soo
dc.contributor.authorLazaro, Luisa
dc.contributor.authorLi, Chiang-shan R.
dc.contributor.authorLochner, Christine
dc.contributor.authorMarsh, Rachel
dc.contributor.authorMartínez-Zalacaín, Ignacio
dc.contributor.authorMataix-Cols, David
dc.contributor.authorMenchón, Jose M.
dc.contributor.authorMinnuzi, Luciano
dc.contributor.authorMoreira, Pedro Silva
dc.contributor.authorMorgado, Pedro
dc.contributor.authorNakagawa, Akiko
dc.contributor.authorNakamae, Takashi
dc.contributor.authorNarayanaswamy, Janardhanan C.
dc.contributor.authorNurmi, Erika L.
dc.contributor.authorOrtiz, Ana E.
dc.contributor.authorPariente, Jose C.
dc.contributor.authorPiacentini, John
dc.contributor.authorPicó-Pérez, Maria
dc.contributor.authorPiras, Fabrizio
dc.contributor.authorPiras, Federica
dc.contributor.authorPittenger, Christopher
dc.contributor.authorReddy, Y. C. Janardhan
dc.contributor.authorRodriguez-Manrique, Daniela
dc.contributor.authorSakai, Yuki
dc.contributor.authorShimizu, Eiji
dc.contributor.authorShivakumar, Venkataram
dc.contributor.authorSimpson, Helen Blair
dc.contributor.authorSoreni, Noam
dc.contributor.authorSoriano-Mas, Carles
dc.contributor.authorSousa, Nuno
dc.contributor.authorSpalletta, Gianfranco
dc.contributor.authorStern, Emily R.
dc.contributor.authorStevens, Michael C.
dc.contributor.authorStewart, S. Evelyn
dc.contributor.authorSzeszko, Philip R.
dc.contributor.authorTakahashi, Jumpei
dc.contributor.authorTanamatis, Tais
dc.contributor.authorTang, Jinsong
dc.contributor.authorThorsen, Anders Lillevik
dc.contributor.authorTolin, David
dc.contributor.authorvan der Werf, Ysbrand D.
dc.contributor.authorvan Marle, Hein
dc.contributor.authorvan Wingen, Guido A.
dc.contributor.authorVecchio, Daniela
dc.contributor.authorVenkatasubramanian, G.
dc.contributor.authorWalitza, Susanne
dc.contributor.authorWang, Jicai
dc.contributor.authorWang, Zhen
dc.contributor.authorWatanabe, Anri
dc.contributor.authorWolters, Lidewij H.
dc.contributor.authorXu, Xiufeng
dc.contributor.authorYun, Je-Yeon
dc.contributor.authorZhao, Qing
dc.contributor.authorWhite, Tonya
dc.contributor.authorThompson, Paul M.
dc.contributor.authorStein, Dan J.
dc.contributor.authorvan den Heuvel, Odile A
dc.contributor.authorVriend, Chris
dc.date.accessioned2023-03-29T12:01:41Z
dc.date.available2023-03-29T12:01:41Z
dc.date.created2022-05-23T13:39:43Z
dc.date.issued2022
dc.identifier.issn2158-3188
dc.identifier.urihttps://hdl.handle.net/11250/3060914
dc.description.abstractLarger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = −0.15 to −0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorderen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber70en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41398-022-01823-2
dc.identifier.cristin2026550
dc.source.journalTranslational Psychiatryen_US
dc.identifier.citationTranslational Psychiatry. 2022, 12, 70.en_US
dc.source.volume12en_US
dc.source.issue1en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal