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dc.contributor.authorJaspers-Fayer, Fern
dc.contributor.authorYao Lin, Sarah
dc.contributor.authorBest, John R.
dc.contributor.authorThorsen, Anders Lillevik
dc.contributor.authorNegreiros, Juliana
dc.contributor.authorChan, Elaine
dc.contributor.authorEllwyn, Rhonda
dc.contributor.authorLin, Boyee
dc.contributor.authorde Wit, Stella
dc.contributor.authorvan den Heuvel, Odile A
dc.contributor.authorStewart, S. Evelyn
dc.date.accessioned2023-03-29T13:17:52Z
dc.date.available2023-03-29T13:17:52Z
dc.date.created2022-12-02T13:43:40Z
dc.date.issued2022
dc.identifier.issn1180-4882
dc.identifier.urihttps://hdl.handle.net/11250/3060948
dc.description.abstractBackground: Pediatric obsessive–compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD. Methods: Before and after a symptom provocation task, youth with OCD (n = 23; 9 boys; mean age ± standard deviation 15.1 ± 2.6 years) and matched healthy controls (n = 23) completed the Tower of London task during functional MRI scanning. Results: During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group × time point interaction; t44 = 5.22, p < 0.001). In a seeded, region of interest–constrained, functional connectivity analysis, we identified greater connectivity between the left superior frontal gyrus and the right middle frontal gyrus, left precuneus and left inferior parietal lobule in participants with OCD than healthy controls. We also identified greater connectivity between the right amygdala and right medial frontal gyrus in patients with OCD than healthy controls, but only before symptom provocation. Limitations: The fixed-order design of the study and the number of participants taking medication (n = 20) should be noted. Conclusion: Participants with OCD demonstrated greater amygdalar–cortical connectivity before symptom provocation, while sustaining greater recruitment and connectivity of task-related planning areas throughout the task. These results suggest that brain activity and connectivity is altered after symptom provocation, in the absence of impaired planning performance.en_US
dc.language.isoengen_US
dc.publisherCmaj Groupen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleAn fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive–compulsive disorderen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 CMA Impact Inc.en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1503/jpn.220064
dc.identifier.cristin2087793
dc.source.journalJournal of Psychiatry & Neuroscienceen_US
dc.source.pagenumberE409-E420en_US
dc.identifier.citationJournal of Psychiatry & Neuroscience. 2022, 47 (6), E409-E420.en_US
dc.source.volume47en_US
dc.source.issue6en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal