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dc.contributor.authorShala, Nita Kaupang
dc.contributor.authorStenehjem, Jo
dc.contributor.authorBabigumira, Ronnie
dc.contributor.authorLiu, Fei-Chih
dc.contributor.authorBerge, Leon Alexander Mclaren
dc.contributor.authorSilverman, Debra T.
dc.contributor.authorFriesen, Melissa C.
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorLan, Qing
dc.contributor.authorHosgood, H. Dean
dc.contributor.authorSamuelsen, Sven Ove
dc.contributor.authorBråtveit, Magne
dc.contributor.authorKirkeleit, Jorunn
dc.contributor.authorAndreassen, Bettina Kulle
dc.contributor.authorVeierød, Marit Bragelien
dc.contributor.authorGrimsrud, Tom Kristian
dc.date.accessioned2024-03-19T10:07:16Z
dc.date.available2024-03-19T10:07:16Z
dc.date.created2023-08-02T10:57:06Z
dc.date.issued2023
dc.identifier.issn0007-0920
dc.identifier.urihttps://hdl.handle.net/11250/3123059
dc.description.abstractBackground Occupational exposures constitute the second leading cause of urinary bladder cancer after tobacco smoking. Increased risks have been found in the petroleum industry, but high-quality exposure data are needed to explain these observations. Methods Using a prospective case-cohort design, we analysed 189 bladder cancer cases (1999–2017) and 2065 randomly drawn non-cases from the Norwegian Offshore Petroleum Workers cohort. Cases were identified in the Cancer Registry of Norway, while work histories (1965–1998) and lifestyle factors were recorded by questionnaire at baseline (1998). Occupational petroleum-related hydrocarbon exposures were assessed by expert-developed job-exposure matrices. Hazard ratios were estimated by weighted Cox-regressions, adjusted for age, tobacco smoking, education, and year of first employment, and with lagged exposures. Results Increased risks were found in benzene-exposed workers, either long-term exposure (≥18.8 years, HR = 1.89, 95% CI: 1.14–3.13; p-trend = 0.044) or high-level cumulative benzene exposure (HR = 1.60, 95% CI: 0.97–2.63; p-trend = 0.065), compared with the unexposed. Associations persisted with 20-year exposure lag. No associations were found with skin or inhalation exposure to crude oil, mineral oil (lubrication, hydraulics, turbines, drilling), or diesel exhaust. Conclusions The results suggest that exposures in the benzene fraction of the petroleum stream may be associated with increased bladder cancer risk.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleExposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workersen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41416-023-02357-0
dc.identifier.cristin2164442
dc.source.journalBritish Journal of Canceren_US
dc.source.pagenumber838-851en_US
dc.identifier.citationBritish Journal of Cancer. 2023, 129 (5), 838-851.en_US
dc.source.volume129en_US
dc.source.issue5en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal