Molecular pathways of mitochondria transfer in Glioblastoma cells
Abstract
Glioblastoma (GBM) is a malignant brain tumor and the most aggressive form of brain cancer in adults. The aggressive nature and invasive properties of GBM cells contribute to the poor prognosis and increased rate of recurrence of the disease. Glioblastoma shows remarkable inter- and intratumoral heterogeneity at the genomic and transcriptomic level which makes these tumors highly resistant to conventional treatments. There is little known about the interaction of glioblastoma with its microenvironment which might in the future reveal new targets for treatment . Recent studies have demonstrated that Tumor Microtubes (MT) are important cell communication structures between GBM and its tumor microenvironment. MTs interconnect tumor cells leading to network formation through which Calcium waves are exchanged. MTs can connect tumor cells also to stromal cells such as astrocytes and facilitate mitochondria transfer. It has been shown that communication through MTs including mitochondria transfer promotes cell survival, invasion, and treatment resistance.
Description
Postponed access: the file will be accessible after 2025-06-03