dc.contributor.author | Hetemäki, Iivo | |
dc.contributor.author | Heikkilä, Nelli | |
dc.contributor.author | Peterson, Pärt | |
dc.contributor.author | Kekäläinen, Eliisa | |
dc.contributor.author | Willcox, Nick | |
dc.contributor.author | Wolff, Anette Susanne Bøe | |
dc.contributor.author | Jarva, Hanna | |
dc.contributor.author | Arstila, T Petteri | |
dc.date.accessioned | 2024-12-06T13:06:47Z | |
dc.date.available | 2024-12-06T13:06:47Z | |
dc.date.created | 2024-08-19T09:59:16Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 0903-4641 | |
dc.identifier.uri | https://hdl.handle.net/11250/3168719 | |
dc.description.abstract | Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, high titer neutralizing anti-type I interferon (IFN) autoantibodies have been linked with increased severity of SARS-CoV-2 and varicella zoster virus infections in APECED patients. Examining immunity against cytomegalovirus (CMV), we found a higher prevalence of anti-CMV IgG antibodies in patients with APECED (N = 19) than in 44 healthy controls (90% vs 64%, p = 0.04); the similar difference in their IgG levels did not achieve significance (95 ± 74 vs 64 ± 35 IU/mL, ns.). In contrast, the frequency of CMV-specific T cells was lower (804 ± 718/million vs 1591 ± 972/million PBMC p = 0.03). We saw no correlations between levels of anti-CMV IgG and anti-IFN antibodies in APECED patients or in a separate cohort of patients with thymoma (n = 70), over 60% of whom also had anti-IFN antibodies. Our results suggest a dysregulated response to CMV in APECED patients and highlight immunodeficiency to viral infections as part of the disease spectrum. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1111/apm.13458 | |
dc.identifier.cristin | 2287341 | |
dc.source.journal | APMIS - Journal of Pathologiy, Microbiology and Immunology | en_US |
dc.source.pagenumber | 881-887 | en_US |
dc.identifier.citation | APMIS - Journal of Pathologiy, Microbiology and Immunology. 2024, 132 (11), 881-887. | en_US |
dc.source.volume | 132 | en_US |
dc.source.issue | 11 | en_US |