• Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial 

      Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Hellem, Sølve; Rojewski, Markus; Gjengedal, Harald; Yassin, Mohammed Ahmed Alamin Yousif; Feng, Xin; Skaale, Siren G; Berge, Trond Inge; Rosén, Annika; Shi, Xieqi; Ahmed, Aymen B; Gjertsen, Bjørn Tore; Schrezenmeier, Hubert; Layrolle, Pierre (Journal article; Peer reviewed, 2018)
      Background Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone ...
    • Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells 

      Suliman, Salwa; Ali, Hassan Mohamed Abdel-Raouf; Karlsen, Tommy Aleksander; Amiaud, Jérôme; Mohamed Ahmed, Samih; Layrolle, Pierre; Costea, Daniela Elena; Brinchmann, Jan E.; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-11-05)
      Therapeutic potential of human bone marrow stromal/stem cells (hBMSC) must be developed using well defined xenogenic-free conditions. hBMSC were isolated from healthy donors (n = 3) using different isolation and expansion ...
    • Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data 

      Rojewski, Markus Thomas; Lofti, Ramin; Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Veronesi, Elena; Ahmed, Aymen B; Wiesneth, Markus; Körper, Sixten; Sensebé, Luc; Layrolle, Pierre; Hellem, Sølve; Schrezenmeier, Hubert (Journal article; Peer reviewed, 2019)
      Background Many data are available on expansion protocols for mesenchymal stromal cells (MSCs) for both experimental settings and manufacturing for clinical trials. However, there is a lack of information on translation ...