• A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks 

      Al-jibury, Ediem; King, James W. D.; Guo, Ya; Lenhard, Boris; Fisher, Amanda G.; Merkenschlager, Matthias; Rueckert, Daniel (Journal article; Peer reviewed, 2023)
      The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that provide rich data ...
    • Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis 

      Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)
      Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ...
    • Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data 

      Kolar, Kushal; Dondorp, Daniel; Zwiggelaar, Jordi Cornelis; Høyer, Jørgen; Chatzigeorgiou, Marios (Journal article; Peer reviewed, 2021)
      Calcium imaging is an increasingly valuable technique for understanding neural circuits, neuroethology, and cellular mechanisms. The analysis of calcium imaging data presents challenges in image processing, data organization, ...
    • Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin 

      Weiss, Felix D.; Calderon, Lesly; Wang, Yi-Fang; Georgieva, Radina; Guo, Ya; Cvetesic, Nevena; Kaur, Maninder; Dharmalingam, Gopuraja; Krantz, Ian D.; Lenhard, Boris; Fisher, Amanda G.; Merkenschlager, Matthias (Journal article; Peer reviewed, 2021)
      Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet ...
    • NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis 

      Lemaitre, Quentin Indiana Bruno; Bartsch, Natascha; Kouzel, Ivan; Busengdal, Henriette; Richards, Gemma Sian; Steinmetz, Patrick; Rentzsch, Fabian (Journal article; Peer reviewed, 2023)
      Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian ...
    • RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions 

      Bonetti, Alessandro; Agostini, Federico; Suzuki, Ana Maria; Hashimoto, Kosuke; Pascarella, Giovanni; Gimenez, Juliette; Roos, Leonie; Nash, Alex J.; Ghilotti, Marco; Cameron, Christopher J.  F.; Valentine, Matthew; Medvedeva, Yulia A.; Noguchi, Shuhei; Agirre, Eneritz; Kashi, Kaori; Samudyata, Samudyata; Luginbühl, Joachim; Cazzoli, Riccardo; Agrawal, Saumya; Luscombe, Nicholas M.; Blanchette, Mathieu; Kasukawa, Takeya; de Hoon, Michiel; Arner, Erik; Lenhard, Boris; Plessy, Charles; Castelo-Branco, Gonçalo; Orlando, Valerio; Carninci, Piero (Journal article; Peer reviewed, 2020)
      Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ...