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dc.contributor.authorSkoie, Inger Marieen_US
dc.contributor.authorTernowitz, Thomasen_US
dc.contributor.authorJonsson, Greteen_US
dc.contributor.authorNorheim, Katrine Brækkeen_US
dc.contributor.authorOmdal, Roalden_US
dc.date.accessioned2015-08-17T11:55:31Z
dc.date.available2015-08-17T11:55:31Z
dc.date.issued2015-05
dc.identifier.issn0007-0963
dc.identifier.urihttps://hdl.handle.net/1956/10287
dc.description.abstractFatigue is a prevalent and substantial phenomenon in many patients with chronic inflammatory diseases, often rated by patients as the most troublesome symptom and aspect of their disease. It frequently interferes with physical and social functions and may lead to social withdrawal, long-standing sick leave and disability. Although psychological and somatic factors such as depression, sleep disorders, pain and anaemia influence fatigue, the underlying pathophysiological mechanisms by which fatigue is generated and regulated are largely unknown. Increasing evidence points towards a genetic and molecular basis for fatigue as part of the innate immune system and cellular stress responses. Few studies have focused on fatigue in dermatological diseases. Most of these studies describe fatigue as a phenomenon related to psoriatic arthritis and describe the beneficial effects of biological agents on fatigue observed in clinical studies. It is therefore possible that this problem has been underestimated and deserves more attention in the dermatological community. In this review, we provide a definition and explanation for chronic fatigue, describe some commonly used instruments for measuring fatigue, and present hypothetical biological mechanisms with an emphasis on activation of the innate immune system and oxidative stress. An overview of relevant clinical studies covering the theme ‘psoriasis and fatigue’ is given.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.titleFatigue in psoriasis: a phenomenon to be exploreden_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-08-17T11:39:19Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 The Authors
dc.identifier.doihttps://doi.org/10.1111/bjd.13647
dc.identifier.cristin1223157
dc.source.journalBritish Journal of Dermatology
dc.source.40172
dc.source.145
dc.source.pagenumber1196-1203
dc.identifier.citationBritish Journal of Dermatology. 2015, 172, 1196-1203.


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