Browsing Department of Informatics by Author "Alcorn, Melissa R."

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Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

Flowers, Sagen; Kothari, Rushali; Torres Cleuren, Yamila Nicole; Alcorn, Melissa R.; Ewe, Chee Kiang; Alok, Geneva; Fiallo, Samantha L.; Joshi, Pradeep M.; Rothman, Joel H. (Journal article; Peer reviewed, 2023)

The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators ...