Browsing Department of Chemistry by Title
Now showing items 107-126 of 448
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Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
(Journal article, 2014)Structure–activity relationship studies of the cyclopentapeptide CXCR4 antagonists (cyclo(-l-/d-Arg1-Arg2-2-Nal3-Gly4-d-Tyr5-)) suggest that the l-/d-Arg1-Arg2-2-Nal3 tripeptide sequence contained within these cyclopentapeptides ... -
Desorption of sulfamethoxazole from polyamide 6 microplastics: Environmental factors, simulated gastrointestinal fluids, and desorption mechanisms
(Journal article; Peer reviewed, 2023)Microplastics (MPs) can enrich pollutants after being released into the environment, and the contaminants-loaded MPs are usually ingested by organisms, resulting in a potential dual biotoxic effect. In this paper, the ... -
Development and optimisation of processes for active pharmaceutical ingredients:A modern approach to the synthesis of the potent anti-leukaemia drug -Quinacrine
(Master thesis, 2022-08-15)The extensive testing and approval needed before a new active pharmaceutical can be used in treatments of patients has lead to an increased interest in drug repurposing of older approved drugs as treatments for other ... -
Development and validation of a novel method for serotonin and 5-hydroxyindole-acetic acid determination in plasma using liquid chromatography tandem mass spectrometry
(Master thesis, 2014-05-07)5-Hydroxytryptamine (5-HT) also known as serotonin is a biomarker in gastrointestinal disorder and several other pathological diseases where 5-HT and its metabolite 5-hydroxyindole-acetic acid are implicated. A sensitive ... -
Development of a novel extraction method for the analysis of prostaglandins and leukotrienes in fish liver by using liquid chromatography mass spectrometry
(Master thesis, 2015-09-06)Eicosanoids are the major metabolites of fatty acids and they have pro-inflammatory anti-inflammatory proprieties, their role and production in solid biological tissue is important due to correlation with many kinds of ... -
Development of a solid phase extraction method for evaluating the production of classic and nonclassic eicosanoids in human and fish cells using liquid chromatography tandem mass spectrometry
(Master thesis, 2014-03-14)Eicosanoids are the major metabolites of fatty acids and they are correlated with many kinds of diseases such as Alzheimer's, cancer and cardiovascular diseases. Usually, most of the eicosanoids derived from omega-6 fatty ... -
Development of an extraction method for the analysis of pro-inflammatory prostaglandin-E2 and leukotriene-B4 in human plasma by liquid chromatography tandem mass spectrometry
(Master thesis, 2013-02-21)A simple and rapid method for extracting PGE2 and LTB4 from human plasma and further determination by LC-MS/MS proposed and validated. Extracting solvents, formic acid (10 µL) and acetonitrile (140 µL) were added subsequently ... -
Development of an imaging method for in vivo single-cell tracking under high-noise conditions: a proof of principle
(Journal article; Peer reviewed, 2023)This paper reports the development of a positron imaging method for in vivo single-cell tracking under high-noise conditions. Following biological processes spatially and temporally at a single-cell level in a living ... -
Development of Endothelial Barrier Models for Nanotoxicity Testing
(Master thesis, 2022-02-07)Nanotechnology is a field of both research and innovation that is ever-growing. It Is the study and manipulation of matter at the nanoscale to produce materials and devices with enhanced properties. Industries are spending ... -
Development of Methodology for the Synthesis of Cytotoxic NHC-Ag-Complexes
(Master thesis, 2016-06-02)Recently disclosed silver N-heterocyclic carbene complexes holding 4-alkylated imidazoles have been proved to hold cytotoxic properties. In this work, derivatives of such alkylated imidazoles were synthesised to be complexed ... -
Development of methods based on NIR and Raman spectroscopies together with chemometric tools for the qualitative and quantitative analysis of gasoline
(Master thesis, 2019-09-28)Gasoline quality control is essential for SI engines performance and to reduce environmental impacts by generation of undesirable pollutants. Methods established by the American Society for Test and Materials (ASTM) are ... -
Development of Small Molecules that Post-Transitionally Stabilizes the SMN Protein for the Treatment of Spinal Muscular Atrophy
(Master thesis, 2019-08-31)Spinal Muscular Atrophy is an autosomal recessive neurodegenerative disorder, caused by the lack of SMN genes. Previous work done by Laboratory for Drug Discovery in Neurodegeneration (LDDN) at Brigham and Women’s Hospital ... -
Development, validation and application of in-silico methods to predict the macromolecular targets of small organic compounds
(Doctoral thesis, 2021-12-10)Computational methods to predict the macromolecular targets of small organic drugs and drug-like compounds play a key role in early drug discovery and drug repurposing efforts. These methods are developed by building ... -
Di-μ-chlorido-bis{bis[N,N-bis(trimethylsilyl)amido]titanium(III)}
(Journal article; Peer reviewed, 2017)The molecular structure of the title compound, [Ti2Cl2(C6H18NSi2)4], shows a binuclear motif of TiIII atoms, formulated as [Ti(μ-Cl)(N(SiMe3)2)2]2, with two μ-Cl atoms bridging two ((Me3Si)2N)2Ti moieties. The coordination ... -
Diels-Alder reactions with 1,1-diethoxybut-3-yn-2-one and some 1,1-diethoxy-5-hydroxyalk-3-yn-2-ones and their acetates
(Journal article; Peer reviewed, 2020) -
Dimethyl 3,3′-dimethoxybiphenyl-4,4′-dicarboxylate
(Peer reviewed; Journal article, 2014)In the title compound, C18H18O6, the biphenyl moiety is twisted with a dihedral angle of 29.11 (10)°. The carbomethoxy groups form C-C-C-O torsion angles of -18.3 (3) and -27.7 (3)° with the attached rings, as a result ... -
Direct Injection Electrospray Mass Spectrometry (DI-ESI-MS) and Liquid Chromatography Electrospray Mass Spectrometry (LC-ESI-MS) method development for characterisation of organic acids in petroleum and bio-oil samples
(Master thesis, 2017-05-09)Analysis and characterisation of complex mixtures such as petroleum and bio-oils are unarguably challenging. Finding suitable analytical method therefore needs to be considered carefully by analytical chemists. Electrospray ... -
Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
(Journal article; Peer reviewed, 2024)Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated ... -
Discrimination of n-3 Rich Oils by Gas Chromatography
(Peer reviewed; Journal article, 2010-11-22)Exploring the capabilities of instrumental techniques for discriminating n-3 rich oils derived from animals is a very important though much neglected area that was emphasized more than 100 years ago. In this study the ... -
Dissecting peripheral protein-membrane interfaces
(Journal article; Peer reviewed, 2022-12-14)Peripheral membrane proteins (PMPs) include a wide variety of proteins that have in common to bind transiently to the chemically complex interfacial region of membranes through their interfacial binding site (IBS). In ...