Browsing Department of Chemistry by Title
Now showing items 401-420 of 449
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Synthesis of Some Nitrogen Heterocycles of Medicinal Relevance
(Doctoral thesis, 2012-04-18)In the first part of the project, two highly functionalized terminal alkynes, 3,3,4,4- tetraethoxybut-1-yne (TEB) and 1,1-diethoxy-but-3-yn-2-one (keto-TEB) have been used for the synthesis of 1,4-disubstituted 1,2,3-triazoles. ... -
Synthesis of substituted imidazoles that stabilizes Survival Motor Neuron Protein for treatment of Spinal Muscular Atrophy
(Master thesis, 2019-08-31)Spinal muscular atrophy (SMA) is a common autosomal recessive disorder and the leading cause of infant mortality. Patients with this disorder are missing the SMN1 gene that is producing 80-90 % of the Spinal motor neuron ... -
Synthesis, Characterization and Catalytic Applications of N-Heterocyclic Carbene Based Vanadium Complexes.
(Master thesis, 2022-05-31)New tri- and tetradentate O-functionalized NHC oxo- and imido vanadium complexes have been synthesized and characterized. The complexes were preliminary tested for catalytic activity towards coupling of CO2 and epoxides ... -
Synthetic studies toward [18F]-fluorination of solid-supported silyl ethers
(Doctoral thesis, 2023-05-25)Molekylær avbildning er definert som visualisering av in vivo biologiske prosesser på molekylært- eller cellulært nivå. Dette krever bruk av prober og kan gi anatomisk samt funksjonell informasjon. Molekylær avbildning ... -
TAT-Modified Gold Nanoparticles Enhance the Antitumor Activity of PAD4 Inhibitors
(Journal article; Peer reviewed, 2020)Purpose: Histone citrullination by peptidylarginine deiminases 4 (PAD4) regulates the gene expression of tumor suppressor. In our previously study, YW3-56 (356) was developed as a potent PAD4 inhibitor for cancer therapy ... -
Technetium-99 (99Tc) in the North and Nordic Seas – the present status (2010) and a compilation of the Institute of Marine Research’s monitoring data (2003-2009)
(Master thesis, 2011-04-26)Technetium-99 (99Tc) is an anthropogenic, pure β-emitting (Emax = 292 keV) radionuclide with a half-life of 2.13 · 10^5 years. It is present in the marine environment primarily due to discharges from nuclear fuel reprocessing ... -
Tegn på forståelse av kjemi i elevrapporter: En undersøkelse av elevrapporter i programfag i kjemi
(Master thesis, 2018-06-26)Praktisk arbeid i realfagsundervisning er et tema som er mye diskutert i forskningen. Særlig problemstillinger som omhandler læringsutbyttet av praktisk arbeid er mye forsket på, og i den sammenheng også rapportene som ... -
A Theoretical Study of Cr/oxide Catalysts for Dehydrogenation of Short Alkanes
(Doctoral thesis, 2006-10-27)Natural gas reserves are being produced at increasing rates world wide, thus providing an abundance of short-alkane feedstock for the petrochemical industry. Effective routes to selective activation of short alkanes may ... -
Theory-Based Mechanistic Insight as Stepping Stone for Catalyst Development in Olefin Polymerization
(Doctoral thesis, 2011-09-29) -
Thermal stability of polyphenols and carotenoids from Laminaria hyperborea
(Master thesis, 2024-06-03)The green shift, and the focus on an increased blue bioeconomy, has stimulated the growth of sustainable production lines for marine bioactive products for food-, feed-, cosmetics-, and -pharmaceutical industries. Norway ... -
TiO2/Fe2O3 heterostructures with enhanced photocatalytic reduction of Cr(VI) under visible light irradiation
(Peer reviewed; Journal article, 2019-07-23)We report a study on the synthesis of TiO2/Fe2O3 (TF) nanocomposites and their photocatalytic performance under visible-light irradiation. The characterization of structure and morphology shows that hematite Fe2O3 was ... -
Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei
(Journal article; Peer reviewed, 2023)Microplastics (MPs) pose one of the major environmental threats to marine organisms and ecosystems on a global scale. Although many marine crustaceans are highly susceptible to MPs pollution, the toxicological effects and ... -
Total Synthesis of Phorbazole B
(Journal article; Peer reviewed, 2020)Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the ... -
Totalkvikksølv og metylkvikksølv i filet og lever av brosme fiska i Boknafjorden, samanlikna med Hardangerfjorden og Lofoten
(Master thesis, 2014-11-20)Det har i lang tid vore kjend at Hardangerfjorden er forureina, spesielt innerst i fjorden. Tidlegare masteroppgåver som er blitt gjort ved NIFES har funne kvikksølvkonsentrasjonar i brosme (Brosme brosme) frå Hardangerfjorden ... -
Toward E-selective Olefin Metathesis: Computational Design and Experimental Realization of Ruthenium Thio-Indolate Catalysts
(Journal article; Peer reviewed, 2021)The selective transformation of 1-alkenes into E-olefins is a long-standing challenge in olefin metathesis. Density functional theory (DFT) calculations predict high E-selectivity for catalysts incorporating a bidentate, ... -
Towards a Synthesis of the Marine Alkaloid Naamidine B
(Master thesis, 2014-09-15) -
Towards the Synthesis of β-Hydroxy 1,3-Dithiane Derivatives
(Master thesis, 2019-10-03)The β-hydroxy dithiane, 3-(1,3-dithiane-2-yl)-1,1-diethoxypropan-2-ol, was synthesized from the versatile synthon 3,3,4,4-tetraethoxybut-1-yne (TEB). 1,1-Diethoxy-3-(2-methyl-1,3- dithian-2-yl)propan-2-ol was successfully ... -
Toxicity prediction using target, interactome, and pathway profiles as descriptors
(Journal article; Peer reviewed, 2023)In silico methods are essential to the safety evaluation of chemicals. Computational risk assessment offers several approaches, with data science and knowledge-based methods becoming an increasingly important sub-group. ... -
Toxicological evaluation of complex mixtures by pattern recognition: Correlating chemical fingerprints to mutagenicity
(Journal article, 2002-12)We describe the use of pattern recognition and multivariate regression in the assessment of complex mixtures by correlating chemical fingerprints to the mutagenicity of the mixtures. Mixtures were 20 organic extracts of ... -
Transport of polymer particles in oil–water flow in porous media: Enhancing oil recovery
(Peer reviewed; Journal article, 2019)We study a heuristic, core-scale model for the transport of polymer particles in a two-phase (oil and water) porous medium. We are motivated by recent experimental observations which report increased oil recovery when ...