Browsing Department of Chemistry by Author "Gavin, Anne-Claude"

Now showing items 1-2 of 2

    • Membrane specificity of the human cholesterol transfer protein STARD4 

      Talandashti, Reza; van Ek, Larissa; Gehin, Charlotte; Xue, Dandan; Moqadam, Mahmoud; Gavin, Anne-Claude; Reuter, Nathalie (Journal article; Peer reviewed, 2024)
      STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the ...

    • A Membrane-Assisted Mechanism for the Release of Ceramide from the CERT START Domain 

      Moqadam, Mahmoud; Gartan, Parveen; Talandashti, Reza; Chiapparino, Antonella; Titeca, Kevin; Gavin, Anne-Claude; Reuter, Nathalie (Journal article; Peer reviewed, 2024)
      Ceramide transfer protein CERT is the mediator of nonvesicular transfer of ceramide from the ER to Golgi. In CERT, START is the domain responsible for the binding and transport of ceramide. A wealth of structural data has ...