Browsing Department of Mathematics by Author "Frøysa, Håvard G"
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Experimental design for parameter estimation in steady-state linear models of metabolic networks
Frøysa, Håvard G; Skaug, Hans J.; Alendal, Guttorm (Journal article; Peer reviewed, 2020-01)Metabolic networks are typically large, containing many metabolites and reactions. Dynamical models that aim to simulate such networks will consist of a large number of ordinary differential equations, with many kinetic ... -
New Conceptual Toxicokinetic Model to Assess Synergistic Mixture Effects between the Aromatic Hydrocarbon β-Naphthoflavone and the Azole Nocodazole on the CYP1A Biomarker in a Fish Cell Line
Fallahi, Shirin; Mlnaříková, Marie; Alvord, Charlotte; Alendal, Guttorm; Frøysa, Håvard G; Lundh, Thorbjörn; Celander, Malin C. (Journal article; Peer reviewed, 2020)Toxicokinetic interactions with catabolic cytochrome P450 (CYP) enzymes can inhibit chemical elimination pathways and cause synergistic mixture effects. We have created a mathematical bottom-up model for a synergistic ...