Browsing Department of Mathematics by Author "Jones, Nick"

Now showing items 1-3 of 3

    • Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations 

      Hoitzing, Hanne; Gammage, Payam; van Haute, Lindsey; Minczuk, Michal; Johnston, Iain; Jones, Nick (Peer reviewed; Journal article, 2019-06-26)
      The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved ...

    • Mitochondrial network state scales mtDNA genetic dynamics 

      Aryaman, Juvid; Bowles, Charlotte; Jones, Nick; Johnston, Iain George (Peer reviewed; Journal article, 2019)
      Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. mtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion ...

    • Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data 

      Johnston, Iain George; Hoffmann, Till; Greenbury, Sam; Cominetti, Ornella; Jallow, Muminatou; Kwiatkowski, Dominic; Barahona, Mauricio; Jones, Nick; Casals-Pascual, Climent (Peer reviewed; Journal article, 2019)
      More than 400,000 deaths from severe malaria (SM) are reported every year, mainly in African children. The diversity of clinical presentations associated with SM indicates important differences in disease pathogenesis that ...