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dc.contributor.authorVik, Alexandraen_US
dc.contributor.authorHodneland, Erlenden_US
dc.contributor.authorHaász, Juditen_US
dc.contributor.authorYstad, Martin Andreasen_US
dc.contributor.authorLundervold, Astrien_US
dc.contributor.authorLundervold, Arviden_US
dc.PublishedFrontiers in Aging Neuroscience 2015, 7:81eng
dc.description.abstractMotivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal areas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions [3D T1-weighted and diffusion weighted imaging (DWI)] were obtained from healthy older adults (N = 76, range 49–80 years at inclusion) at two time points, 3 years apart. A subset of the participants (N = 24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connectivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.en_US
dc.rightsAttribution CC BYeng
dc.subjectDiffusion weighted imagingeng
dc.subject3D MRIeng
dc.subjectfractional anisotropyeng
dc.subjecttract parametrizationeng
dc.subjecthealthy agingeng
dc.subjectlongitudinal studyeng
dc.subjectfrontal-subcortical fiberseng
dc.titleFractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adultsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 Vik, Hodneland, Haász, Ystad, Lundervold and Lundervold
dc.subject.nsiVDP::Samfunnsvitenskap: 200::Psykologi: 260::Biologisk psykologi: 261
dc.subject.nsiVDP::Social sciences: 200::Psychology: 260::Biological psychology: 261
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Neurology: 752
dc.subject.nsiVDP::Medisinske Fag: 700en_US

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