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dc.contributor.authorHocking, William Peter
dc.contributor.authorRoalkvam, Irene
dc.contributor.authorMagnussen, Carina
dc.contributor.authorStokke, Runar
dc.contributor.authorSteen, Ida Helene
dc.date.accessioned2016-02-23T09:39:14Z
dc.date.available2016-02-23T09:39:14Z
dc.date.issued2015
dc.PublishedArchaea 2015, 2015:235384eng
dc.identifier.issn1472-3654en_US
dc.identifier.urihttp://hdl.handle.net/1956/11291
dc.description.abstractThe hyperthermophilic, sulfate-reducing archaeon, Archaeoglobus fulgidus, utilizes CO as an energy source and it is resistant to the toxic effects of high CO concentrations. Herein, transcription profiles were obtained from A. fulgidus during growth with CO and sulfate or thiosulfate, or without an electron acceptor. This provided a basis for a model of the CO metabolism of A. fulgidus. The model suggests proton translocation by “Mitchell-type” loops facilitated by Fqo catalyzing a :menaquinone oxidoreductase reaction, as the major mode of energy conservation, rather than formate or H2 cycling during respiratory growth. The bifunctional CODH (cdhAB-2) is predicted to play an ubiquitous role in the metabolism of CO, and a novel nitrate reductase-associated respiratory complex was induced specifically in the presence of sulfate. A potential role of this complex in relation to and APS reduction is discussed. Multiple membrane-bound heterodisulfide reductase (DsrMK) could promote both energy-conserving and non-energy-conserving menaquinol oxidation. Finally, the FqoF subunit may catalyze a :F420 oxidoreductase reaction. In the absence of electron acceptor, downregulation of F420H2 dependent steps of the acetyl-CoA pathway is linked to transient formate generation. Overall, carboxidotrophic growth seems as an intrinsic capacity of A. fulgidus with little need for novel resistance or respiratory complexes.en_US
dc.language.isoengeng
dc.publisherHindawien_US
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.titleAssessment of the carbon monoxide metabolism of the hyperthermophilic sulfate-reducing archaeon Archaeoglobus fulgidus VC-16 by comparative transcriptome analysesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-12-31T16:25:22Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authorsen_US
dc.identifier.doihttps://doi.org/10.1155/2015/235384
dc.identifier.cristin1256927
dc.relation.projectNorges forskningsråd: 179560


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