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dc.contributor.authorDavies, Gailen_US
dc.contributor.authorArmstrong, Nen_US
dc.contributor.authorBis, JCen_US
dc.contributor.authorBressler, Jen_US
dc.contributor.authorChouraki, Ven_US
dc.contributor.authorGiddaluru, Sudheeren_US
dc.contributor.authorHofer, Een_US
dc.contributor.authorIbrahim-Verbaas, CAen_US
dc.contributor.authorKirin, Men_US
dc.contributor.authorLahti, Jen_US
dc.contributor.authorVan Der Lee, SJen_US
dc.contributor.authorLe Hellard, Stephanieen_US
dc.contributor.authorLiu, Ten_US
dc.contributor.authorMarioni, REen_US
dc.contributor.authorOldmeadow, Cen_US
dc.contributor.authorPostmus, Ien_US
dc.contributor.authorSmith, AVen_US
dc.contributor.authorSmith, JAen_US
dc.contributor.authorThalamuthu, Aen_US
dc.contributor.authorThomson, Ren_US
dc.contributor.authorVitart, Ven_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorYu, Len_US
dc.contributor.authorZgaga, Len_US
dc.contributor.authorZhao, Wen_US
dc.contributor.authorBoxall, Ren_US
dc.contributor.authorHarris, SEen_US
dc.contributor.authorHill, WDen_US
dc.contributor.authorLiewald, DCen_US
dc.contributor.authorLuciano, Men_US
dc.contributor.authorAdams, Hen_US
dc.contributor.authorAmes, Den_US
dc.contributor.authorAmin, Nen_US
dc.contributor.authorAmouyel, Pen_US
dc.contributor.authorAssareh, AAen_US
dc.contributor.authorAu, Ren_US
dc.contributor.authorBecker, JTen_US
dc.contributor.authorBeiser, Aen_US
dc.contributor.authorBerr, Cen_US
dc.contributor.authorBertram, Len_US
dc.contributor.authorBoerwinkle, Een_US
dc.contributor.authorBuckley, BMen_US
dc.contributor.authorCampbell, Hen_US
dc.contributor.authorCorley, Jen_US
dc.contributor.authorDe Jager, PLen_US
dc.contributor.authorDufouil, Cen_US
dc.contributor.authorEriksson, JGen_US
dc.contributor.authorEspeseth, Thomasen_US
dc.contributor.authorFaul, JDen_US
dc.contributor.authorFord, Ien_US
dc.contributor.authorScotland, Generationen_US
dc.contributor.authorGottesman, RFen_US
dc.contributor.authorGriswold, MEen_US
dc.contributor.authorGudnason, Ven_US
dc.contributor.authorHarris, TBen_US
dc.contributor.authorHeiss, Gen_US
dc.contributor.authorHofman, Aen_US
dc.contributor.authorHolliday, EGen_US
dc.contributor.authorHuffman, Jen_US
dc.contributor.authorKardia, SLRen_US
dc.contributor.authorKochan, Nen_US
dc.contributor.authorKnopman, DSen_US
dc.contributor.authorKwok, JBen_US
dc.contributor.authorLambert, JCen_US
dc.contributor.authorLee, Ten_US
dc.contributor.authorLi, Gen_US
dc.contributor.authorLi, SCen_US
dc.contributor.authorLoitfelder, Men_US
dc.contributor.authorLopez, OLen_US
dc.contributor.authorLundervold, Astrien_US
dc.contributor.authorLundqvist, Aen_US
dc.contributor.authorMather, KAen_US
dc.contributor.authorMirza, SSen_US
dc.contributor.authorNyberg, Len_US
dc.contributor.authorOostra, BAen_US
dc.contributor.authorPalotie, Aen_US
dc.contributor.authorPapenberg, Gen_US
dc.contributor.authorPattie, Aen_US
dc.contributor.authorPetrovic, Ken_US
dc.contributor.authorPolasek, Oen_US
dc.contributor.authorPsaty, BMen_US
dc.contributor.authorRedmond, Pen_US
dc.contributor.authorReppermund, Sen_US
dc.contributor.authorRotter, JIen_US
dc.contributor.authorSchmidt, Hen_US
dc.contributor.authorSchuur, Men_US
dc.contributor.authorSchofield, PWen_US
dc.contributor.authorScott, RJen_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorStott, DJen_US
dc.contributor.authorVan Swieten, JCen_US
dc.contributor.authorTaylor, KDen_US
dc.contributor.authorTrollor, Jen_US
dc.contributor.authorTrompet, Sen_US
dc.contributor.authorUitterlinden, AGen_US
dc.contributor.authorWeinstein, Gen_US
dc.contributor.authorWiden, Een_US
dc.contributor.authorWindham, BGen_US
dc.contributor.authorJukema, JWen_US
dc.contributor.authorWright, AFen_US
dc.contributor.authorWright, MJen_US
dc.contributor.authorYang, Qen_US
dc.contributor.authorAmieva, Hen_US
dc.contributor.authorAttia, JRen_US
dc.contributor.authorBennett, DAen_US
dc.contributor.authorBrodaty, Hen_US
dc.contributor.authorDe Craen, AJMen_US
dc.contributor.authorHayward, Cen_US
dc.contributor.authorIkram, MAen_US
dc.contributor.authorLindenberger, Uen_US
dc.contributor.authorNilsson, LGen_US
dc.contributor.authorPorteous, DJen_US
dc.contributor.authorRäikkönen, Ken_US
dc.contributor.authorRudan, Ien_US
dc.contributor.authorSachdev, PSen_US
dc.contributor.authorSchmidt, Ren_US
dc.contributor.authorSchofield, PRen_US
dc.contributor.authorSrikanth, Ven_US
dc.contributor.authorStarr, JMen_US
dc.contributor.authorTurner, STen_US
dc.contributor.authorWeir, DRen_US
dc.contributor.authorWilson, JFen_US
dc.contributor.authorVan Duijn, Cen_US
dc.contributor.authorLauner, Len_US
dc.contributor.authorFitzpatrick, ALen_US
dc.contributor.authorSeshadri, Sen_US
dc.contributor.authorMosley, THen_US
dc.contributor.authorDeary, IJen_US
dc.contributor.authorReinvang, Ivaren_US
dc.date.accessioned2016-03-02T14:10:24Z
dc.date.available2016-03-02T14:10:24Z
dc.date.issued2015
dc.PublishedMolecular Psychiatry 2015, 20(2):183-192eng
dc.identifier.issn1476-5578
dc.identifier.urihttps://hdl.handle.net/1956/11419
dc.description.abstractGeneral cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10−9, MIR2113; rs17522122, P=2.55 × 10−8, AKAP6; rs10119, P=5.67 × 10−9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10−6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10−17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer’s disease: TOMM40, APOE, ABCG1 and MEF2C.en_US
dc.language.isoengeng
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleGenetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-12-30T17:10:59Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authors
dc.identifier.doihttps://doi.org/10.1038/mp.2014.188
dc.identifier.cristin1275878
dc.subject.nsiVDP::Samfunnsvitenskap: 200::Psykologi: 260::Kognitiv psykologi: 267
dc.subject.nsiVDP::Social sciences: 200::Psychology: 260::Cognitive psychology: 267
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714


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