• Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model 

      Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)
      Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ...
    • Dynamics of Plasma and Urinary Extracellular DNA in Acute Kidney Injury 

      Jančuška, Alexander; Potočárová, Alena; Kovalčíková, Alexandra Gaál; Podracká, L’Udmila; Babickova, Janka; Celec, Peter; Tóthová, L’Ubomíra (Journal article; Peer reviewed, 2022)
      Early and reliable markers of acute kidney injury (AKI) are essential. One such candidate marker of tissue damage is extracellular DNA (ecDNA). The aim of our present study is to describe the unknown dynamics of ecDNA in ...
    • The Effect of Melatonin on Periodontitis 

      Konečná, Barbora; Chobodová, Paulína; Janko, Jakub; Baňasová, Lenka; Babickova, Janka; Celec, Peter; Tóthová, L’Ubomíra (Journal article; Peer reviewed, 2021)
      Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute ...
    • Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission 

      Vrablicova, Zuzana; Tomova, Kristina; Tothova, Lubomira; Babickova, Janka; Gromova, Barbora; Konecna, Barbora; Liptak, Robert; Hlavaty, Tibor; Gardlik, Roman (Journal article; Peer reviewed, 2020)
      Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ...
    • Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers 

      Gyurászová, Marianna; Gurecká, Radana; Babickova, Janka; Tóthová, Ľubomíra (Journal article; Peer reviewed, 2020)
      Kidney disease represents a serious global health problem. One of the main concerns is its late diagnosis, only feasible in a progressed disease state. The lack of a clinical manifestation in the early stages and the fact ...
    • Plasma Concentrations of Extracellular DNA in Acute Kidney Injury 

      Homolová, Jordanka; Janovičová, L'ubica; Konečná, Barbora; Vlková, Barbora; Celec, Peter; Tóthová, L'ubomíra; Babickova, Janka (Journal article; Peer reviewed, 2020)
      Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma. A rapid turnover ...
    • Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype 

      Elsaid, Hassan Osman Alhassan; Furriol, Jessica; Blomqvist, Maria; Diswall, Mette; Leh, Sabine; Gharbi, Naouel; Anonsen, Jan Haug; Babickova, Janka; Tøndel, Camilla; Svarstad, Einar; Marti, Hans Peter; Krause, Maximilian (Journal article; Peer reviewed, 2022)
      Fabry disease (FD) is a rare genetic lysosomal storage disorder, resulting from partial or complete lack of alpha-galactosidase A (α-GAL) enzyme, leading to systemic accumulation of substrate glycosphingolipids with a broad ...
    • Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys 

      Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)
      The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...