• 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans 

      Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi; Ellegaard, Maria; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Bøen, Rune; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Ching, Christopher R. K.; Cichon, Sven; Ciufolini, Simone; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dale, Anders M.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J. C.; Zubicaray, Greig I. de; Zwarte, Sonja M. C. de; Desrivieres, Sylvane; Doherty, Joanne L.; Donohoe, Gary; Draganski, Bogdan; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fejgin, Kim; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Ge, Tian; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Haberg, Asta Kristine; Hall, Jeremy; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek P.; Hillegers, Manon H. J.; Hoffmann, Per; Holleran, Laurena; Holmes, Avram J.; Johansson, Stefan; Jönsson, Erik Gunnar; Hellard, Stephanie Francoise Claire Le; Lundervold, Arvid; Lundervold, Astri J.; Moberget, Torgeir; Nordvik, Jan Egil; Sando, Sigrid Botne; Steen, Vidar Martin; Tamnes, Christian Krog; Agartz, Ingrid; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole; Homuth, Georg; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jahanshad, Neda; Jockwitz, Christiane; Jørgensen, Niklas R.; Kikuchi, Masataka; Knowles, Emma E. M.; Kumar, Kuldeep; Leu, Costin; Linden, David E. J.; Liu, Jingyu; Maillard, Anne M.; Martin, Nicholas G.; Martin-Brevet, Sandra; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Meyer-Lindenberg, Andreas; Modenato, Claudia; Monereo Sánchez, Jennifer; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nielsen, Jacob; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomas; Pausova, Zdenka; Peralta, Juan M.; Pike, G. Bruce; Prieto, Carlos; Quinlan, Erin B.; Reinbold, Céline S.; Reis Marques, Tiago; Rucker, James J. H.; Sachdev, Perminder S.; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Stein, Dan J.; Strike, Lachlan T.; Suzuki, Ikuo K.; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ulfarsson, Magnus O.; van ‘t Ent, Dennis; van den Bree, Marianne B. M.; Vanderhaeghen, Pierre; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Stefansson, Hreinn; Stefansson, Kari; Jacquemont, Sébastien; Thompson, Paul M. (Journal article; Peer reviewed, 2021)
      Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers ...
    • ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications 

      Homaei, Selina Cannon; Barone, Helene; Kleppe, Rune; Betari, Nibal; Reif, Andreas; Haavik, Jan (Journal article; Peer reviewed, 2021)
      Neurometabolic diseases (NMDs) are typically caused by genetic abnormalities affecting enzyme functions, which in turn interfere with normal development and activity of the nervous system. Although the individual disorders ...
    • Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets 

      Postema, Merel C.; Hoogman, Martine; Ambrosino, Sara; Asherson, Philip; Banaschewski, Tobias; Bandeira, Cibele E.; Baranov, Alexandr; Bau, Claiton H.D.; Baumeister, Sarah; Baur-Streubel, Ramona; Bellgrove, Mark A.; Biederman, Joseph; Bralten, Janita; Brandeis, Daniel; Brem, Silvia; Buitelaar, Jan K.; Busatto, Geraldo F.; Castellanos, Francisco X.; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Chantiluke, Kaylita C.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Cubillo, Ana; Cupertino, Renata B.; de Zeeuw, Patrick; Doyle, Alysa E.; Durston, Sarah; Earl, Eric A.; Epstein, Jeffery N.; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Faraone, Stephen V.; Frodl, Thomas; Gabel, Matt C.; Gogberashvili, Tinatin; Grevet, Eugenio H.; Haavik, Jan; Harrison, Neil A.; Hartman, Catharina A.; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Hohmann, Sarah; Høvik, Marie Farstad; Jernigan, Terry L.; Kardatzki, Bernd; Karkashadze, George A.; Kelly, Clare; Kohls, Gregor; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lera-Miguel, Sara; Lesch, Klaus-Peter; Louza, Mario R.; Lundervold, Astri J.; Malpas, Charles B.; Mattos, Paulo; McCarthy, Hazel; Namazova-Baranova, Leyla; Nicolau, Rosa; Nigg, Joel T.; Novotny, Stephanie E.; Oberwelland Weiss, Eileen; O'Gorman Tuura, Ruth L.; Oosterlaan, Jaap; Oranje, Bob; Paloyelis, Yannis; Pauli, Paul; Picon, Felipe A.; Plessen, Kerstin J.; Ramos-Quiroga, J. Antoni; Reif, Andreas; Reneman, Liesbeth; Rosa, Pedro G.P.; Rubia, Katya; Schrantee, Anouk; Schweren, Lizanne J.S.; Seitz, Jochen; Shaw, Philip; Silk, Tim J.; Skokauskas, Norbert; Soliva, Joan Carles; Stevens, Michael C.; Sudre, Gustavo; Tamm, Leanne; Tovar-Moll, Fernanda; van Erp, Theo G.M.; Vance, Alasdair; Vilarroya, Oscar; Vives-Gilabert, Yolanda; von Polier, Georg G.; Walitza, Susanne; Yoncheva, Yuliya N.; Zanetti, Marcus V; Ziegler, Georg C.; Glahn, David C.; Jahanshad, Neda; Medland, Sarah E.; Thompson, Paul M.; Fisher, Simon E.; Franke, Barbara; Francks, Clyde (Journal article; Peer reviewed, 2021)
      Objective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the ...
    • Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy 

      Erchinger, Vera Jane; Miller, Jeremy; Jones, Thomas; Kessler, Ute; Bustillo, Juan R.; Haavik, Jan; Petrillo, Jonathan; Ziomek, Gregory; Hammar, Åsa; Ødegaard, Ketil Joachim; Calhoun, Vince D.; McClintock, Shawn M.; Ersland, Lars; Oltedal, Leif; Abbott, Christopher (Journal article; Peer reviewed, 2020-09-17)
      Objective The anticonvulsant hypothesis posits that ECT’s mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory ...
    • Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview 

      Hartman, Catharina A.; Larsson, Henrik; Vos, Melissa; Bellato, Alessio; Libutzki, Berit; Solberg, Berit Skretting; Chen, Qi; Du Rietz, Ebba; Mostert, Jeanette C.; Kittel-Schneider, Sarah; Cormand, Bru; Ribasés, Marta; Klungsøyr, Kari; Haavik, Jan; Dalsgaard, Søren; Cortese, Samuele; Faraone, Stephen; Reif, Andreas (Journal article; Peer reviewed, 2023)
      Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) ...
    • Association of sweetened carbonated beverage consumption during pregnancy and ADHD symptoms in the ofspring: a study from the Norwegian Mother, Father and Child Cohort Study (MoBa) 

      Kvalvik, Liv Grimstvedt; Klungsøyr, Kari; Igland, Jannicke; Caspersen, Ida Henriette; Brantsæter, Anne Lise; Solberg, Berit Skretting; Hartman, Catharina; Schweren, Lizanne Johanna Stephanie; Larsson, Henrik; Li, Lin; Forthun, Ingeborg; Johansson, Stefan; Vasquez, Alejandro Arias; Haavik, Jan (Journal article; Peer reviewed, 2022)
      Purpose Intrauterine exposures influence offspring health and development. Here we investigated maternal intake of sweetened carbonated beverages (SCB) during pregnancy and its association with ADHD symptoms in the ...
    • Attention-deficit/hyperactivity disorder and smoking habits in pregnant women 

      Anderson, Anneli; Hegvik, Tor-Arne; Chen, Qi; Kvalvik, Liv Grimstvedt; Almqvist, Catarina; D'Onofrio, Brian M.; Hartman, Catharina A; Klungsøyr, Kari; Haavik, Jan; Tuvblad, Catherine; Larsson, Henrik (Journal article; Peer reviewed, 2020)
      Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with an increased risk of tobacco smoking, and more difficulties with smoking cessation compared to non-ADHD individuals. Women with ADHD may ...
    • Case report: ADHD and prognosis in tyrosinemia type 1 

      Halleland, Helene; Elgen, Irene Bircow; Bliksrud, Yngve Thomas; Hansen, Eirik Vangsøy; Skavhellen, Rita Rigmor; Furevik, Magne Ivar; Haavik, Jan (Journal article; Peer reviewed, 2023-07-18)
      Neurometabolic disorders such as tyrosinemia type 1 (TYRSN1) may interfere with brain metabolism and show symptoms of attention-deficit hyperactivity disorder (ADHD) in patients treated with the enzyme inhibitor nitisinone ...
    • Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT-A Systematic Review 

      Aarsland, Tore Ivar Malmei; Instanes, Johanne Telnes; Posserud, Maj-Britt Rocio; Ulvik, Arve; Kessler, Ute; Haavik, Jan (Journal article; Peer reviewed, 2022)
      The kynurenine pathway of tryptophan (Trp) metabolism generates multiple biologically active metabolites (kynurenines) that have been implicated in neuropsychiatric disorders. It has been suggested that modulation of ...
    • Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure 

      Hoogman, Martine; Van Rooij, Daan; Klein, Marieke; Boedhoe, Premika; Ilioska, Iva; Li, Ting; Patel, Yash; Postema, Merel C.; Zhang-James, Yanli; Anagnostou, Evdokia; Arango, Celso; Auzias, Guillaume; Banaschewski, Tobias; Bau, Claiton H.D.; Behrmann, Marlene; Bellgrove, Mark A.; Brandeis, Daniel; Brem, Silvia; Busatto, Geraldo F.; Calderoni, Sara; Calvo, Rosa; Castellanos, Francisco X.; Coghill, David; Conzelmann, Annette; Daly, Eileen; Deruelle, Christine; Dinstein, Ilan; Durston, Sarah; Ecker, Christine; Ehrlich, Stefan; Epstein, Jeffery N.; Fair, Damien A.; Fitzgerald, Jacqueline; Freitag, Christine; Frodl, Thomas; Gallagher, Louise; Grevet, Eugenio H.; Haavik, Jan; Hoekstra, Pieter J.; Janssen, Joost; Karkashadze, George A.; King, Joseph A.; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lerch, Jason P.; Lesch, Klaus-Peter; Louza, Mario R.; Luna, Beatriz; Mattos, Paulo; McGrath, Jane; Muratori, Filippo; Murphy, Clodagh; Nigg, Joel T.; Oberwelland Weiss, Eileen; O'Gorman Tuura, Ruth L.; O'Hearn, Kirsten; Oosterlaan, Jaap; Parellada, Mara; Pauli, Paul; Plessen, Kerstin von; Ramos-Quiroga, Josep Antoni; Reif, Andreas; Reneman, Liesbeth; Retico, Alessandra; Rosa, Pedro G.; Rubia, Katya; Shaw, Philip; Silk, Tim J.; Tamm, Leanne; Vilarroya, Oscar; Walitza, Susanne; Jahanshad, Neda; Faraone, Stephen V.; Francks, Clyde; van den Heuvel, Odile A.; Paus, Tomáš; Thompson, Paul M.; Buitelaar, Jan; Franke, Barbara (Journal article; Peer reviewed, 2020)
      Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main ...
    • Current and Retrospective Childhood Ratings of Emotional Fluctuations in Adults With ADHD 

      Lundervold, Astri J.; Halmøy, Anne; Nordby, Emilie Sektnan; Haavik, Jan; Meza, Jocelyn I. (Journal article; Peer reviewed, 2020)
      Introduction: Emotional fluctuations and mood swings are common among adults with Attention Deficit/Hyperactivity Disorder (ADHD). Here we investigated if these problems could be retrospectively traced back to childhood ...
    • Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality 

      Oddsson, Asmundur; Sulem, Patrick; Sveinbjornsson, Gardar; Arnadottir, Gudny A.; Steinthorsdottir, Valgerdur; Halldorsson, Gisli H.; Atlason, Bjarni A.; Oskarsson, Gudjon R.; Helgason, Hannes; Nielsen, Henriette Svarre; Westergaard, David; Karjalainen, Juha; Katrinardottir, Hildigunnur; Fridriksdottir, Run; Jensson, Brynjar O.; Tragante, Vinicius; Ferkingstad, Egil; Jónsson, Hákon; Gudjonsson, Sigurjon A.; Beyter, Doruk; Moore, Kristjan H.S.; Thordardottir, Helga B.; Kristmundsdottir, Snædis; Stefansson, Olafur A.; Rantapää Dahlqvist, Solbritt; Sonderby, Ida Elken; Didriksen, Maria; Stridh, Pernilla; Haavik, Jan; Tryggvadottir, Laufey; Frei, Oleksandr; Walters, G. Bragi; Kockum, Ingrid; Hjalgrim, Henrik; Olafsdottir, Thorunn A; Selbæk, Geir; Nyegaard, Mette; Erikstrup, Christian; Brodersen, Thorsten; Sævarsdottir, Sædis; Olsson, Tomas; Nielsen, Kaspar Rene; Haraldsson, Àsgeir; Bruun, Mie Topholm; Hansen, Thomas Folkmann; Steingrimsdottir, Thora; Jacobsen, Rikke Louise; Lie, Rolv T.; Djurovic, Srdjan; Alfredsson, Lars; Portilla, A.L.; Brunak, Søren; Havdahl, Alexandra; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with ...
    • Diet quality, stress and common mental health problems: A cohort study of 121,008 adults 

      Schweren, Lizanne J.S.; Larsson, Henrik; Vinke, Petra C.; Li, Lin; Kvalvik, Liv Grimstvedt; Arias-Vasquez, Alejandro; Haavik, Jan; Hartman, Catharina A. (Journal article; Peer reviewed, 2021)
      Background & aims Overall diet quality may partially mediate the detrimental effects of stress and neuroticism on common mental health problems: stressed and/or neurotic individuals may be more prone to unhealthy dietary ...
    • Diet, Physical Activity, and Disinhibition in Middle-Aged and Older Adults: A UK Biobank Study 

      Schweren, Lizanne J.S.; van Rooij, Daan; Shi, Huiqing; Larsson, Henrik; Arias-Vasquez, Alejandro; Li, Lin; Kvalvik, Liv Grimstvedt; Haavik, Jan; Buitelaar, Jan; Hartman, Catharina (Journal article; Peer reviewed, 2021)
      Disinhibition is a prominent feature of multiple psychiatric disorders, and has been associated with poor long-term somatic outcomes. Modifiable lifestyle factors including diet and moderate-to-vigorous physical activity ...
    • Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis 

      Betari, Nibal; Sahlholm, Kristoffer; Ishizuka, Yuta; Teigen, Knut; Haavik, Jan (Journal article; Peer reviewed, 2020)
      Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Selective TPH1 inhibitors may be useful for treating disorders related to serotonin dysregulation. Results & methodology: Screening ...
    • Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population? 

      Xie, Tian; Schweren, Lizanne J.S.; Larsson, Henrik; Li, Lin; Rietz, Ebba Du; Haavik, Jan; Kvalvik, Liv Grimstvedt; Solberg, Berit Skretting; Klungsøyr, Kari; Snieder, Harold; Hartman, Catharina A. (Journal article; Peer reviewed, 2023-03-27)
      The present study investigated whether an unhealthy diet and other lifestyle behaviors may modify the genetic susceptibility to impulsivity. A total of 33,047 participants (mean age = 42.1 years, 59.8% females) from the ...
    • The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression 

      Aarsland, Tore Ivar Malmei; Haavik, Jan; Ulvik, Arve; Ueland, Per Magne; Dols, Annemiek; Kessler, Ute (Journal article; Peer reviewed, 2023)
      Background Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while ...
    • Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs 

      Sønderby, Ida Elken; Ching, Christopher R. K.; Thomopoulos, Sophia I.; van der Meer, Dennis; Sun, Daqiang; Villalon-Reina, Julio E.; Agartz, Ingrid; Amunts, Katrin; Arango, Celso; Armstrong, Nicola J.; Ayesa-Arriola, Rosa; Bakker, Geor; Bassett, Anne S.; Boomsma, Dorret I.; Bulow, Robin; Butcher, Nancy J.; Calhoun, Vince D.; Caspers, Svenja; Chow, Eva W. C.; Cichon, Sven; Ciufolini, Simone; Craig, Michael C.; Crespo-Facorro, Benedicto; Cunningham, Adam C.; Dale, Anders M.; Dazzan, Paola; de Zubicaray, Greig I.; Djurovic, Srdjan; Doherty, Joanne L.; Donohoe, Gary; Draganski, Bogdan; Durdle, Courtney A.; Ehrlich, Stefan; Emanuel, Beverly S.; Espeseth, Thomas; Fisher, Simon E.; Ge, Tian; Glahn, David C.; Grabe, Hans J.; Gur, Raquel E.; Gutman, Boris A.; Lundervold, Astri J.; Haavik, Jan; Håberg, Asta; Hansen, Laura A.; Moberget, Torgeir; Sánchez, Jennifer Monereo; Reinbold, Céline Sonja; Tamnes, Christian Krog; Westlye, Lars Tjelta; Andreassen, Ole; et al., , (Journal article; Peer reviewed, 2022)
      The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors ...
    • The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders 

      Szigetvari, Peter Daniel; Patil, Sudarshan; Birkeland, Even; Kleppe, Rune; Haavik, Jan (Journal article; Peer reviewed, 2023)
      Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, resulting in phenylalanine accumulation and impaired tyrosine production. In Tyrosinemia ...
    • Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate 

      Erchinger, Vera Jane; Craven, Alexander R.; Ersland, Lars; Oedegaard, Ketil J.; Bartz-Johannessen, Christoffer; Hammar, Åsa Karin; Haavik, Jan; Riemer, Frank; Kessler, Ute; Oltedal, Leif (Journal article; Peer reviewed, 2023)
      Introduction: Based on previous research on electroconvulsive therapy (ECT) we have proposed a model where disruption, potentiation, and rewiring of brain networks occur in sequence and serve as the underlying therapeutic ...