Browsing University of Bergen Library by Journals "EMBO Molecular Medicine"

Now showing items 1-2 of 2

    • Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations 

      Liang, Xiao; Kristiansen, Cecilie Katrin; Mostafavi, Sepideh; Vatne, Guro H.; Zantingh, Gina; Kianian, Atefeh; Tzoulis, Charalampos; Høyland, Lena Elise; Ziegler, Mathias; Perez, Roberto Megias; Furriol, Jessica; Zhang, Zhuoyuan; Balafkan, Novin; Hong, Yu; Siller, Richard; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)
      Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using ...

    • Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis 

      Guyon, Joris; Fernandez-Moncada, Ignacio; Larrieu, Claire M; Bouchez, Cyrielle L; Pagano Zottola, Antonio C; Galvis, Johanna; Chouleur, Tiffanie; Burban, Audrey; Joseph, Kevin; Ravi, Vidhya M; Espedal, Heidi; Røsland, Gro Vatne; Daher, Boutaina; Barre, Aurélien; Dartigues, Benjamin; Karkar, Slim; Rudewicz, Justine; Romero-Garmendia, Irati; Klink, Barbara; Grützmann, Konrad; Derieppe, Marie-Alix; Molinié, Thibaut; Obad, Nina; Léon, Céline; Seano, Giorgio; Miletic, Hrvoje; Heiland, Dieter Henrik; Marsicano, Giovanni; Nikolski, Macha; Bjerkvig, Rolf; Bikfalvi, Andreas; Daubon, Thomas (Journal article; Peer reviewed, 2022)
      Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ...