Blar i University of Bergen Library på tidsskrift "Frontiers in Endocrinology"
Viser treff 1-10 av 10
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eQTLs as causal instruments for the reconstruction of hormone linked gene networks
(Journal article; Peer reviewed, 2022)Hormones act within in highly dynamic systems and much of the phenotypic response to variation in hormone levels is mediated by changes in gene expression. The increase in the number and power of large genetic association ... -
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
(Journal article; Peer reviewed, 2020)Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and ... -
Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation
(Journal article; Peer reviewed, 2021)New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that ... -
Metabolic and Epigenetic Regulation by Estrogen in Adipocytes
(Journal article; Peer reviewed, 2022-02-22)Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ... -
Multi-omics and machine learning for the prevention and management of female reproductive health
(Journal article; Peer reviewed, 2023)Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women’s ... -
Neurohypophysial and paracrine vasopressinergic signaling regulates aquaporin trafficking to hydrate marine teleost oocytes
(Journal article; Peer reviewed, 2023)The dual aquaporin (Aqp1ab1/Aqp1ab2)-mediated hydration of marine teleost eggs, which occurs during oocyte meiosis resumption (maturation), is considered a key adaptation underpinning their evolutionary success in the ... -
Peripheral and central macrophages in obesity
(Journal article; Peer reviewed, 2023)Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells ... -
Plasma cortisol linked gene networks in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk
(Journal article; Peer reviewed, 2023)Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular ... -
Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency
(Journal article; Peer reviewed, 2021)Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ... -
Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance
(Journal article; Peer reviewed, 2022)A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis ...