• Antipsychotic drug use in pregnancy: A multinational study from ten countries 

      Reutfors, Johan; Cesta, Carolyn; Cohen, Jacqueline Mallory; Bateman, Brian T; Brauer, Ruth; Einarsdottir, Kristjana; Engeland, Anders; Furu, Kari; Gissler, Mika; Havard, Alys; Hernandez-Diaz, Sonia; Huybrechts, Krista F.; Karlstad, Øystein; Leinonen, Maarit; Li, Jiong; Man, Kenneth K. C.; Pazzagli, Laura; Schaffer, Andrea; Schink, Tania; Wang, Zixuan; Yu, Yongfu; Zoega, Helga; Bröms, Gabriella (Journal article; Peer reviewed, 2020)
      Aim To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland ...
    • Association between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute psychosis 

      Fathian, Farivar; Gjestad, Rolf; Kroken, Rune Andreas; Løberg, Else-Marie; Reitan, Solveig Merete Klæbo; Fleichhacker, W. Wolfgang; Rettenbacher, Maria; Larsen, Tor Ketil; Joa, Inge; Stabell, Lena Antonsen; Kjelby, Eirik; Sinkevicute, Igne; Alisauskiene, Renata; Steen, Vidar Martin; Johnsen, Erik (Journal article; Peer reviewed, 2022)
      Background A potential role of inflammatory pathways in the pathology of schizophrenia has been suggested for at least a subgroup of patients. Elevated levels of the inflammatory marker C-reactive protein (CRP) have been ...
    • Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study 

      Hoprekstad, Gunnhild Eldhuset; Kjelby, Eirik; Gjestad, Rolf; Fathian, Farivar; Larsen, Tor Ketil; Reitan, Solveig Klæbo; Rettenbacher, Maria; Torsvik, Anja; Skrede, Silje; Johnsen, Erik; Kroken, Rune Andreas (Journal article; Peer reviewed, 2023)
      Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity in the immune system is seen in both depression and schizophrenia. We aimed to uncover depressive trajectories in a sample ...
    • Hostility and aggressive behaviour in first episode psychosis: Results from the OPTiMiSE trial 

      Faay, Margo D.M.; van Baal, G. Caroline M.; Arango, Celso; Diaz-Caneja, Covadonga M.; Berger, Gregor; Leucht, Stefan; Bobes, Julio; Saiz, Pilar A.; García-Portilla, María Paz; van de Brug, Resy; Petter, Jocelyn; Winter-van Rossum, Inge; Sommer, Iris Else Clara (Journal article; Peer reviewed, 2020)
      Aim: The aim of this paper is to determine clinical factors related to hostility and disturbing and aggressive behaviour and to examine the effect of medication on these behaviours in FEP. Methods: Data from phase I and ...
    • Impact of childhood trauma on antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, semi-randomized trial 

      Mørkved, Nina; Johnsen, Erik; Kroken, Rune Andreas; Winje, Dagfinn; Larsen, Tor Ketil; Thimm, Jens; Rettenbacher, M.A.; Johannesen, C.A. Bartz; Løberg, Else-Marie (Journal article; Peer reviewed, 2022)
      Antipsychotic medications are generally effective in ameliorating psychotic symptoms in schizophrenia spectrum disorders (SSDs). Identifying predictors associated with poor treatment response is important for a personalized ...
    • Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Nils Eiel (Journal article; Peer reviewed, 2020)
      Background One third of people diagnosed with schizophrenia fail to respond adequately to antipsychotic medication, resulting in persisting disabling symptoms, higher rates of hospitalization and higher costs for society. ...
    • Mortality and non-use of antipsychotic drugs after acute admission in schizophrenia: A prospective total-cohort study 

      Strømme, Maria Fagerbakke; Mellesdal, Liv Solrunn; Bartz-Johannesen, Christoffer; Kroken, Rune Andreas; Krogenes, Marianne; Mehlum, Lars; Johnsen, Erik (Journal article; Peer reviewed, 2021)
      Background In society at large, it is debated whether use of antipsychotic drugs is associated with increased or decreased mortality among patients with schizophrenia. Large register studies have demonstrated an increased ...
    • Overactive, aggressive, disruptive and agitated behavior associated with the use of psychotropic medications in schizophrenia 

      Strømme, Maria Fagerbakke; Bartz-Johannessen, Christoffer; Kroken, Rune Andreas; Mehlum, Lars; Johnsen, Erik (Journal article; Peer reviewed, 2022)
      Background Evidence is limited for the associations between use of psychotropic medications and overactive, aggressive, disruptive or agitated behavior (OADA)1 in clinical practice. Aims To investigate the associations ...