• Accuracy and efficiency of germline variant calling pipelines for human genome data 

      Zhao, Sen; Agafonov, Oleg; Azab, Abdulrahman; Stokowy, Tomasz; Hovig, Eivind (Journal article; Peer reviewed, 2020)
      Advances in next-generation sequencing technology have enabled whole genome sequencing (WGS) to be widely used for identification of causal variants in a spectrum of genetic-related disorders, and provided new insight into ...
    • Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination 

      Eide, Thea Tislevoll; Hufthammer, Karl Ove; Brun, Atle; Brackman, Damien; Svarstad, Einar; Tøndel, Camilla (Journal article; Peer reviewed, 2021)
      Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling ...
    • AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study 

      Hong, Yu; Liang, Kristina Xiao; Gilhus, Nils Erik (Journal article; Peer reviewed, 2020-07-08)
      Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, ...
    • Atlantic salmon and sea trout display synchronised smolt migration relative to linked environmental cues 

      Harvey, Alison C.; Glover, Kevin; Wennevik, Vidar; Skaala, Øystein (Journal article; Peer reviewed, 2020)
      Anadromous salmon and sea trout smolts face challenging migrations from freshwater to the marine environment characterised by high mortality. Therefore, the timing of smolt migration is likely to be critical for survival. ...
    • Automated segmentation of endometrial cancer on MR images using deep learning 

      Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Solteszova, Veronika; Zanna, Antonella; Fasmer, Kristine Eldevik; Krakstad, Camilla; Lundervold, Arvid; Lundervold, Alexander Selvikvåg; Salvesen, Øyvind; Erickson, Bradley J.; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume tumor analyses ...
    • Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer 

      Krüger, Kristi; Silwal-Pandit, Laxmi; Wik, Elisabeth; Straume, Oddbjørn; Stefansson, Ingunn Marie; Borgen, Elin; Garred, Øystein; Naume, Bjørn; Engebråten, Olav; Akslen, Lars Andreas (Journal article; Peer reviewed, 2021)
      A subset of breast cancer patients benefits from preoperative bevacizumab and chemotherapy, but validated predictive biomarkers are lacking. Here, we aimed to evaluate tissue-based angiogenesis markers for potential ...
    • Brain solute transport is more rapid in periarterial than perivenous spaces 

      Vinje, Vegard; Bakker, Erik N. T. P.; Rognes, Marie Elisabeth (Journal article; Peer reviewed, 2021)
      Fluid flow in perivascular spaces is recognized as a key component underlying brain transport and clearance. An important open question is how and to what extent differences in vessel type or geometry affect perivascular ...
    • Century-long cod otolith biochronology reveals individual growth plasticity in response to temperature 

      Smolinski, Szymon; Deplanque-Lasserre, Julie; Hjörleifsson, Einar; Geffen, Audrey J.; Godiksen, Jane Aanestad; Campana, Steven E. (Journal article; Peer reviewed, 2020)
      Otolith biochronologies combine growth records from individual fish to produce long-term growth sequences, which can help to disentangle individual from population-level responses to environmental variability. This study ...
    • Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis 

      Mosleth, Ellen Færgestad; Vedeler, Christian Alexander; Liland, Kristian Hovde; McLeod, Anette; Bringeland, Gerd Haga; Kroondijk, Liesbeth; Berven, Frode Steingrimsen; Lysenko, Artem; Rawlings, Christopher J.; El-Hajj Eid, Karim; Opsahl, Jill Anette; Gjertsen, Bjørn Tore; Myhr, Kjell-Morten; Gavasso, Sonia (Journal article; Peer reviewed, 2021-02-18)
      Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease ...
    • Changes in the gene expression profile during spontaneous migraine attacks 

      Kogelman, Lisette J.A.; Falkenberg, Katrine; Buil, Alfonso; Erola, Pau; Courraud, Julie; Laursen, Susan Svane; Michoel, Tom Luk Robert; Olesen, Jes; Hansen, Thomas F. (Journal article; Peer reviewed, 2021)
      Migraine attacks are delimited, allowing investigation of changes during and outside attack. Gene expression fluctuates according to environmental and endogenous events and therefore, we hypothesized that changes in RNA ...
    • The chemical defensome of five model teleost fish 

      Eide, Marta; Zhang, Xiaokang; Karlsen, Odd André; Goldstone, Jared V.; Stegeman, John; Jonassen, Inge; Goksøyr, Anders (Journal article; Peer reviewed, 2021)
      How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and ...
    • Cognitive and MRI trajectories for prediction of Alzheimer’s disease 

      Abolpour Mofrad, Samaneh; Lundervold, Astri Johansen; Vik, Alexandra; Lundervold, Alexander Selvikvåg (Journal article; Peer reviewed, 2021)
      The concept of Mild Cognitive Impairment (MCI) is used to describe the early stages of Alzheimer’s disease (AD), and identification and treatment before further decline is an important clinical task. We selected longitudinal ...
    • Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids 

      Marti, Andrea Rørvik; Pedersen, Torhild; Wisor, Jonathan P.; Mrdalj, Jelena; Holmelid, Øystein; Patil, Sudarshan; Meerlo, Peter; Bramham, Clive R.; Grønli, Janne (Journal article; Peer reviewed, 2020)
      Many occupations require operations during the night-time when the internal circadian clock promotes sleep, in many cases resulting in impairments in cognitive performance and brain functioning. Here, we use a rat model ...
    • Coherent electron displacement for quantum information processing using attosecond single cycle pulses 

      Agueny, Hicham (Journal article; Peer reviewed, 2020)
      Coherent electron displacement is a conventional strategy for processing quantum information, as it enables to interconnect distinct sites in a network of atoms. The efficiency of the processing relies on the precise control ...
    • COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1 

      Dankel, Simon N; Grytten, Elise; Bjune, Jan-Inge; Nielsen, Hans Jørgen; Dietrich, Arne; Blüher, Matthias; Sagen, Jørn V.; Mellgren, Gunnar (Journal article; Peer reviewed, 2020)
      Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a ...
    • Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement 

      Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Kristoffersen, Per Martin; Vetti, Nils; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Schistad, Ellina Iordanova; Haugen, Anne Julsrud; Johanessen, Anne Froholdt; Skouen, Jan Sture; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Lie, Benedicte Alexandra (Journal article; Peer reviewed, 2022-01-07)
      Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI ...
    • Disentangling source of moisture driving glacier dynamics and identification of 8.2 ka event: evidence from pore water isotopes, Western Himalaya 

      Kumar, Om; Ramanathan, Al L.; Bakke, Jostein; Kotlia, Bata; Shrivastava, J. P. (Journal article; Peer reviewed, 2020)
      Two atmospheric circulation patterns, the Indian Summer Monsoon (ISM) and mid-latitude Westerlies control precipitation and thus glacier variability in the Himalaya. However, the role of the ISM and westerlies in controlling ...
    • Dynamic switching between intrinsic and extrinsic mode networks as demands change from passive to active processing 

      Riemer, Frank; Gruner, Eli Renate; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Ersland, Lars; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020-12-08)
      In this study we report on the relationship between default and extrinsic mode networks across alternating brief periods of rest and active task processing. Three different visual tasks were used in a classic fMRI ON–OFF ...
    • Earthquake statistics changed by typhoon-driven erosion 

      Steer, Philippe; Jeandet, Louise; Cubas, Nadaya; Marc, Odin; Meunier, Patrick; Simoes, Martine; Cattin, Rodophe; Shyu, J. Bruce H.; Mouyen, Maxime; Liang, Wen-Tzong; Theunissen, Thomas; Chiang, Shou-Hao; Hovius, Niels (Journal article; Peer reviewed, 2020)
      Tectonics and climate-driven surface processes govern the evolution of Earth’s surface topography. Topographic change in turn influences lithospheric deformation, but the elementary scale at which this feedback can be ...
    • Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling 

      Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab; Strand, Berit Løkensgard; Scholz, Hanne; Paulo, Joao A.; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)
      Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating ...