dc.contributor.author | Contreras, Cristina | en_US |
dc.contributor.author | Gonzalez, Francisco | en_US |
dc.contributor.author | Fernø, Johan | en_US |
dc.contributor.author | Diéguez, Carlos | en_US |
dc.contributor.author | Rahmouni, Kamal | en_US |
dc.contributor.author | Nogueiras, Rubén | en_US |
dc.contributor.author | López, Miguel | en_US |
dc.date.accessioned | 2016-03-10T14:02:40Z | |
dc.date.available | 2016-03-10T14:02:40Z | |
dc.date.issued | 2015-06-10 | |
dc.Published | Annals of Medicine 2015, 47(2):150-168 | eng |
dc.identifier.issn | 1365-2060 | |
dc.identifier.uri | https://hdl.handle.net/1956/11605 | |
dc.description.abstract | Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and mitochondrial uncoupling in brown adipocytes. For many years, BAT was considered to be important only in small mammals and newborn humans, but recent data have shown that BAT is also functional in adult humans. On the basis of this evidence, extensive research has been focused on BAT function, where new molecules, such as irisin and bone morphogenetic proteins, particularly BMP7 and BMP8B, as well as novel central factors and new regulatory mechanisms, such as orexins and the canonical ventomedial nucleus of the hypothalamus (VMH) AMP- activated protein kinase (AMPK)–SNS–BAT axis, have been discovered and emerged as potential drug targets to combat obesity. In this review we provide an overview of the complex central regulation of BAT and how different neuronal cell populations co-ordinately work to maintain energy homeostasis. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Taylor & Francis | eng |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject | AMPK | eng |
dc.subject | β -adrenoreceptors | eng |
dc.subject | brown adipose tissue (BAT) | eng |
dc.subject | hypothalamus | eng |
dc.subject | Obesity | eng |
dc.subject | orexins | eng |
dc.subject | sympathetic nervous system (SNS) | eng |
dc.subject | thermogenesis | eng |
dc.subject | thyroid hormone | eng |
dc.subject | uncoupling protein 1 (UCP1) | eng |
dc.title | The brain and brown fat | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-30T17:06:21Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 the authors | |
dc.identifier.doi | https://doi.org/10.3109/07853890.2014.919727 | |
dc.identifier.cristin | 1255391 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715 | |
dc.subject.nsi | VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Neurology: 752 | |