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dc.contributor.authorSuliman, Salwaen_US
dc.contributor.authorParajuli, Himalayaen_US
dc.contributor.authorSun, Yangen_US
dc.contributor.authorJohannessen, Anne Christineen_US
dc.contributor.authorFinne-Wistrand, Annaen_US
dc.contributor.authorMcCormack, Emmeten_US
dc.contributor.authorMustafa, Kamal Babikeir Elnen_US
dc.contributor.authorCostea, Daniela Elenaen_US
dc.PublishedHead and Neck 2015eng
dc.description.abstractBackground: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was to establish an experimental model for precise and noninvasive evaluation of tumorigenic potential of microenvironmental cues in head and neck cancer. Methods: Bioluminescence was chosen to image tumor formation. Early neoplastic oral keratinocyte (DOK) cells were luciferase-transduced (DOKLuc), then tested in nonobese diabetic severe combined immunodeficient IL2rγnull mice either orthotopically (tongue) or subcutaneously for their potential as “screening sensors” for diverse microenvironmental cues. Results: Tumors formed after inoculation of DOKLuc were monitored easier by bioluminescence, and bioluminescence was more sensitive in detecting differences between various microenvironmental cues when compared to manual measurements. Development of tumors from DOKLuc grown on scaffolds was also successfully monitored noninvasively by bioluminescence. Conclusion: The model presented here is a noninvasive and sensitive model for monitoring the impact of various microenvironmental cues on head and neck cancer in vivo.en_US
dc.relation.ispartof<a href="" target="blank">Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response</a>eng
dc.relation.ispartof<a href="" target="blank">Role of integrin a11 in oral carcinogenesis. In vitro and in vivo studies</a>eng
dc.rightsAttribution CC BY-NC-ND 4.0eng
dc.subjecttissue engineeringeng
dc.titleEstablishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authors

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Attribution CC BY-NC-ND 4.0
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