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dc.contributor.authorArteaga-Marrero, Natalia
dc.contributor.authorBrekke Rygh, Cecilie
dc.contributor.authorMainou-Gomez, Jose Francisco
dc.contributor.authorAdamsen, Tom Christian
dc.contributor.authorLutay, Nataliya
dc.contributor.authorReed, Rolf K
dc.contributor.authorOlsen, Dag Rune
dc.PublishedJournal of Translational Medicine. 2015, 13(1):383eng
dc.descriptionErratum published in: Journal of Translational Medicine 2016, 14:59
dc.description.abstractBackground: This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with 18F-Fluoromisonidazole (18F-FMISO) and 18F-Fluorocholine (18F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation. Methods: PET/CT and DCE-US were acquired pre- and post-treatment, at day 0 and day 3, respectively. At day 1, radiation treatment was delivered as a single fraction of 10 Gy. Two experimental groups were tested for treatment response with 18F-FMISO and 18F-FCH. Results: The maximum Standardized Uptake Values (SUVmax) and the mean SUV (SUVmean) for the 18F-FMISO group were decreased after treatment, and the SUVmean of the tumour-to-muscle ratio was correlated to microvessel density (MVD) at day 3. The kurtosis of the amplitude of the contrast uptake A was significantly decreased for the control tumours in the 18F-FCH group. Furthermore, the eliminating rate constant of the contrast agent from the plasma k el derived from DCE-US was negatively correlated to the SUVmean of tumour-to-muscle ratio, necrosis and MVD. Conclusions: The present study suggests that the multimodal approach using 18F-FMISO PET/CT and DCE-US seems reliable in the assessment of both microvasculature and necrosis as validated by histology. Thus, it has valuable diagnostic and prognostic potential for early non-invasive evaluation of radiotherapy.en_US
dc.publisherBioMed Centralen_US
dc.rightsAttribution CC BYeng
dc.titleRadiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole & 18F-Fluorocholine) and DCE-USen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authorsen_US

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