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dc.contributor.authorCarter, Kim Wen_US
dc.contributor.authorFrancis, Richard Wen_US
dc.contributor.authorStoltenberg, Camillaen_US
dc.contributor.authorSurén, Pålen_US
dc.date.accessioned2016-03-30T09:19:47Z
dc.date.available2016-03-30T09:19:47Z
dc.date.issued2015-10-08
dc.PublishedInternational Journal of Epidemiology 2015eng
dc.identifier.issn0300-5771
dc.identifier.urihttps://hdl.handle.net/1956/11770
dc.description.abstractBackground: Research studies exploring the determinants of disease require sufficient statistical power to detect meaningful effects. Sample size is often increased through centralized pooling of disparately located datasets, though ethical, privacy and data ownership issues can often hamper this process. Methods that facilitate the sharing of research data that are sympathetic with these issues and which allow flexible and detailed statistical analyses are therefore in critical need. We have created a software platform for the Virtual Pooling and Analysis of Research data (ViPAR), which employs free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations. Methods: Database federation permits controlled access to remotely located datasets from a central location. The Secure Shell protocol allows data to be securely exchanged between devices over an insecure network. ViPAR combines these free technologies into a solution that facilitates ‘virtual pooling’ where data can be temporarily pooled into computer memory and made available for analysis without the need for permanent central storage. Results: Within the ViPAR infrastructure, remote sites manage their own harmonized research dataset in a database hosted at their site, while a central server hosts the data federation component and a secure analysis portal. When an analysis is initiated, requested data are retrieved from each remote site and virtually pooled at the central site. The data are then analysed by statistical software and, on completion, results of the analysis are returned to the user and the virtually pooled data are removed from memory. Conclusions: ViPAR is a secure, flexible and powerful analysis platform built on open source technology that is currently in use by large international consortia, and is made publicly available at http://bioinformatics.childhealthresearch.org.au/software/vipar/en_US
dc.language.isoengeng
dc.publisherOxford University Press (OUP)eng
dc.relation.urihttp://ije.oxfordjournals.org/content/early/2015/10/08/ije.dyv193.full.pdf
dc.rightsAttribution CC BY-NC 4.0eng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0eng
dc.subjectViPAReng
dc.subjectdata sharingeng
dc.subjectdata federationeng
dc.subjectdata poolingeng
dc.titleViPAR: a software platform for the Virtual Pooling and Analysis of Research Dataen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-01-21T13:45:49Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author 2015
dc.identifier.doihttps://doi.org/10.1093/ije/dyv193
dc.identifier.cristin1319548
dc.subject.nsiVDP::Medisinske Fag: 700en_US


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Attribution CC BY-NC 4.0
Except where otherwise noted, this item's license is described as Attribution CC BY-NC 4.0