Show simple item record

dc.contributor.authorNordal, Hilde Haugedalen_US
dc.contributor.authorBrun, Johan Gen_US
dc.contributor.authorHalse, Anne-Kristineen_US
dc.contributor.authorJonsson, Rolanden_US
dc.contributor.authorFagerhol, Magne Kristofferen_US
dc.contributor.authorHammer, Hilde Berneren_US
dc.PublishedBMC Musculoskeletal Disorders 2014, 15:335eng
dc.description.abstractBackground. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore in a pilot study the associations between S100A12 and other inflammatory markers, clinical assessments as well as degree of synovitis detected by a comprehensive ultrasonography (US) examination in RA patients during biologic treatment. Methods. Twenty patients with RA were examined clinically and by use of US as well as laboratory markers S100A12, calprotectin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) before starting adalimumab, with follow-up after 1, 3, 6 and 12 months. Ultrasonographic B-mode (BM) and power Doppler (PD) assessments of 78 joints, 36 tendons/tendon groups and 2 bursas were performed, and sum US scores calculated. Wilcoxon signed rank test assessed treatment response and Spearman rank correlation test was used to calculate correlations. Results. The concentrations of S100A12 decreased after 3 months (p < 0.01) and significant correlations were found between S100A12 and the other laboratory markers during follow-up (0.50-0.62, p < 0.05). Of the clinical assessments, S100A12 had highest correlations with the assessor’s global VAS (0.46-0.85, p < 0.05). Compared with CRP and ESR, S100A12 showed higher correlations with the sum US scores (both BM and PD), with median (range) correlation coefficients of 0.55 (0.35-0.78 (NS-p < 0.001)) for sum BM scores and 0.45 (0.27-0.75 (NS-p < 0.001)) for sum PD scores. Conclusions. The S100A12 protein was significantly associated with other inflammatory markers, clinical assessments as well as sum US scores, indicating that S100A12 is a potential marker of inflammation in RA patients.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BY 4.0eng
dc.subjectS100 proteinseng
dc.subjectRheumatoid arthritiseng
dc.subjectBiologic therapyeng
dc.titleThe neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumaben_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright Nordal et al.; licensee BioMed Central Ltd. 2014
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Rheumatology: 759
dc.subject.nsiVDP::Medisinske Fag: 700en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY 4.0
Except where otherwise noted, this item's license is described as Attribution CC BY 4.0