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dc.contributor.authorJacobsen, Kaya Kvarmeen_US
dc.contributor.authorNievergelt, Caroline M.en_US
dc.contributor.authorZayats, Tetyanaen_US
dc.contributor.authorGreenwood, Tifany A.en_US
dc.contributor.authorAnttila, Vernerien_US
dc.contributor.authorAkiskal, Hagop Sourenen_US
dc.contributor.authorHaavik, Janen_US
dc.contributor.authorFasmer, Ole Bernten_US
dc.contributor.authorKelsoe, John R.en_US
dc.contributor.authorJohansson, Stefanen_US
dc.contributor.authorØdegaard, Ketil Joachimen_US
dc.PublishedJournal of Affective Disorders 2015, 172:453-461eng
dc.description.abstractBackground. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. Methods. We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS). Results. We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97×10−8, OR: 1.82, 95% CI: 1.47–2.25), although this was not replicated in a smaller sample of 289 migraine cases. Limitations. Our study is based on self-reported migraine. Conclusions. NBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.en_US
dc.publisherElsevier B.V.eng
dc.rightsAttribution CC BY-NC-ND 3.0eng
dc.subjectBipolar disordereng
dc.titleGenome wide association study identifies variants in NBEA associated with migraine in bipolar disorderen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 The Authors
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Psychiatry, child psychiatry: 757
dc.subject.nsiVDP::Medisinske Fag: 700en_US

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