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dc.contributor.authorRuhago, George M.en_US
dc.contributor.authorNgalesoni, Frida Namnyaken_US
dc.contributor.authorRobberstad, Bjarneen_US
dc.contributor.authorNorheim, Ole Frithjofen_US
dc.date.accessioned2016-04-18T12:44:37Z
dc.date.available2016-04-18T12:44:37Z
dc.date.issued2015-04-28
dc.PublishedCost Effectiveness and Resource Allocation 2015, 13(1):7
dc.identifier.issn1478-7547
dc.identifier.urihttps://hdl.handle.net/1956/11925
dc.description.abstractBackground. Globally, diarrhoea is the second leading cause of morbidity and mortality, responsible for the annual loss of about 10% of the total global childhood disease burden. In Tanzania, Rotavirus infection is the major cause of severe diarrhoea and diarrhoeal mortality in children under five years. Immunisation can reduce the burden, and Tanzania added rotavirus vaccine to its national immunisation programme in January 2013. This study explores the cost effectiveness of introducing rotavirus vaccine within the Tanzania Expanded Programme on Immunisation (EPI). Methods. We quantified all health system implementation costs, including programme costs, to calculate the cost effectiveness of adding rotavirus immunisation to EPI and the existing provision of diarrhoea treatment (oral rehydration salts and intravenous fluids) to children. We used ingredients and step down costing methods. Cost and coverage data were collected in 2012 at one urban and one rural district hospital and a health centre in Tanzania. We used Disability Adjusted Life Years (DALYs) as the outcome measure and estimated incremental costs and health outcomes using a Markov transition model with weekly cycles up to a five-year time horizon. Results. The average unit cost per vaccine dose at 93% coverage is USD 8.4, with marked difference between the urban facility USD 5.2; and the rural facility USD 9.8. RV1 vaccine added to current diarrhoea treatment is highly cost effective compared to diarrhoea treatment given alone, with incremental cost effectiveness ratio of USD 112 per DALY averted, varying from US$ 80–218 in sensitivity analysis. The intervention approaches a 100% probability of being cost effective at a much lower level of willingness-to-pay than the USD 609 per capita Tanzania gross domestic product (GDP). Conclusions. The combination of rotavirus immunisation with diarrhoea treatment is likely to be cost effective when willingness to pay for health is higher than USD 112 per DALY. Universal coverage of the vaccine will accelerate progress towards achievement of the child health Millennium Development Goals.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/11926" target="blank"> Economic evaluation and equity impact analysis of interventions for maternal and child health in Tanzania. Evidence for fair and efficient priority setting </a>
dc.rightsAttribution CC BY 4.0eng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectCosteng
dc.subjectCost-effectivenesseng
dc.subjectRotaviruseng
dc.subjectVaccineeng
dc.titleCost-effectiveness of live oral attenuated human rotavirus vaccine in Tanzaniaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright Ruhago et al.; licensee BioMed Central. 2015
dc.identifier.doihttps://doi.org/10.1186/s12962-015-0033-0
dc.identifier.cristin1328405
dc.subject.nsiVDP::Medisinske Fag: 700en_US


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Attribution CC BY 4.0
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution CC BY 4.0