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dc.contributor.authorDing, Yunpengen_US
dc.contributor.authorSvingen, Gard Frodahl Tveitevågen_US
dc.contributor.authorPedersen, Eva Ringdalen_US
dc.contributor.authorGregory, Jesse F.en_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorTell, Grethe Seppolaen_US
dc.contributor.authorNygård, Ottaren_US
dc.PublishedJournal of the American Heart Association 2015eng
dc.description.abstractBackground Glycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. Recently, glycine‐dependent reactions have also been linked to lipid metabolism and cholesterol transport. However, little evidence is available on the association between glycine and coronary heart disease. Therefore, we assessed the association between plasma glycine and acute myocardial infarction (AMI). Methods and Results A total of 4109 participants undergoing coronary angiography for suspected stable angina pectoris were studied. Cox regression was used to estimate the association between plasma glycine and AMI, obtained via linkage to the CVDNOR project. During a median follow‐up of 7.4 years, 616 patients (15.0%) experienced an AMI. Plasma glycine was higher in women than in men and was associated with a more favorable baseline lipid profile and lower prevalence of obesity, hypertension, and diabetes mellitus (all P<0.001). After multivariate adjustment for traditional coronary heart disease risk factors, plasma glycine was inversely associated with risk of AMI (hazard ratio per SD: 0.89; 95% CI, 0.82–0.98; P=0.017). The inverse association was generally stronger in those with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 above the median (all Pinteraction≤0.037). Conclusions Plasma glycine was inversely associated with risk of AMI in patients with suspected stable angina pectoris. The associations were stronger in patients with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 levels above the median. These results motivate further studies to elucidate the relationship between glycine and lipid metabolism, in particular in relation to cholesterol transport and atherosclerosis.en_US
dc.publisherWiley Blackwelleng
dc.relation.ispartof<a href="" target="blank"> MTHFD1 and relevant biomarkers in cardiovascular disease: Observational studies in patients with suspected stable angina pectoris in Norway </a>
dc.rightsAttribution CC BY-NC 4.0eng
dc.subjectamino acidseng
dc.subjectlipids and lipoprotein metabolismeng
dc.subjectmyocardial infarctioneng
dc.titlePlasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectorisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authors
dc.subject.nsiVDP::Medisinske Fag: 700en_US

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Except where otherwise noted, this item's license is described as Attribution CC BY-NC 4.0